Document Detail


Chromosome structure and function in man. 3. Pachytene analysis and indentification of the supernumerary chromosome in a case of Down's syndrome (mongolism).
MedLine Citation:
PMID:  4248157     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recently developed pachytene maps of the two small acrocentric autosomes (numbers 21 and 22) of man have been applied to a case of Down's syndrome mosaic for normal and trisomic cells (46,XY/47,XY,21+). Trivalents in trisomic spermatocytes, and thus the supernumerary chromosome, were recognized as compatible in length and chromomere pattern with the shorter of these two chromosomes at the pachytene stage. With the exception of the region of the centromere and the short arm, association among constituents of the trivalent appeared complete.
Authors:
D A Hungerford; W J Mellman; G B Balaban; G U LaBadie; L R Messatzzia; G Haller
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  67     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1970 Sep 
Date Detail:
Created Date:  1970-11-05     Completed Date:  1970-11-05     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  221-4     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Biopsy
Chromosome Mapping
Chromosomes, Human, 21-22 and Y*
Down Syndrome*
Humans
Male
Mosaicism
Spermatozoa
Testis / cytology
Trisomy
Comments/Corrections

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