| Chromosome rearrangements and the evolution of genome structuring and adaptability. | |
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MedLine Citation:
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PMID: 17322554 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Eukaryotes appear to evolve by micro and macro rearrangements. This is observed not only for long-term evolutionary adaptation, but also in short-term experimental evolution of yeast, Saccharomyces cerevisiae. Moreover, based on these and other experiments it has been postulated that repeat elements, retroposons for example, mediate such events. We study an evolutionary model in which genomes with retroposons and a breaking/repair mechanism are subjected to a changing environment. We show that retroposon-mediated rearrangements can be a beneficial mutational operator for short-term adaptations to a new environment. But simply having the ability of rearranging chromosomes does not imply an advantage over genomes in which only single-gene insertions and deletions occur. Instead, a structuring of the genome is needed: genes that need to be amplified (or deleted) in a new environment have to cluster. We show that genomes hosting retroposons, starting with a random order of genes, will in the long run become organized, which enables (fast) rearrangement-based adaptations to the environment. In other words, our model provides a "proof of principle" that genomes can structure themselves in order to increase the beneficial effect of chromosome rearrangements. |
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Authors:
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Anton Crombach; Paulien Hogeweg |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-02-24 |
Journal Detail:
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Title: Molecular biology and evolution Volume: 24 ISSN: 0737-4038 ISO Abbreviation: Mol. Biol. Evol. Publication Date: 2007 May |
Date Detail:
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Created Date: 2007-05-09 Completed Date: 2007-09-12 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 8501455 Medline TA: Mol Biol Evol Country: United States |
Other Details:
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Languages: eng Pagination: 1130-9 Citation Subset: IM |
Affiliation:
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Theoretical Biology and Bioinformatics Group, Utrecht University, Padualaan, Utrecht, The Netherlands. a.b.m.crombach@uu.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Biological
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genetics* Chromosomes Evolution, Molecular Gene Rearrangement* Genetic Variation Models, Genetic* Mutation Retroelements / genetics* Selection, Genetic Terminal Repeat Sequences |
| Chemical | |
Reg. No./Substance:
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0/Retroelements |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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