Document Detail


Chromosome mapping of the CYC7 gene determining yeast iso-2-cytochrome c: structural and regulatory regions.
MedLine Citation:
PMID:  206899     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The primary structures of iso-1-cytochrome c and iso-2-cytochrome c in the yeast Saccharomyces cerevisiae are determined by the genes CYC1 and CYC7, respectively. The CYC1 locus was previously shown to be on the right arm of chromosome X, and the CYC7 locus is shown in this investigation to be on the left arm of chromosome V closely linked to the min1 and mak10 markers. The CYC7 locus appears to be composed of a structural region and a regulatory region. Mutations in the structural region can cause a deficiency or alteration of iso-2-cytochrome c, whereas mutations in the regulatory region can cause increases in the amount of iso-2-cytochrome c. Single-site gene conversion, occurring at a relatively high frequency of approximately 4%, caused intragenic recombination of a mutational site in the structural region and a mutational site in the regulatory region, enabling us to suggest the order of the sites in relationship to other markers on the chromosome.
Authors:
F Sherman; J W Stewart; C Helms; J A Downie
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  75     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1978 Mar 
Date Detail:
Created Date:  1978-07-15     Completed Date:  1978-07-15     Revised Date:  2010-09-02    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1437-41     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Chromosome Mapping
Cytochrome c Group / genetics*,  metabolism
Genes*
Genes, Regulator*
Linkage (Genetics)
Saccharomyces cerevisiae / genetics*
Chemical
Reg. No./Substance:
0/Cytochrome c Group
Comments/Corrections

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