| Chromosome instability induced in the cell progeny of human T lymphocytes irradiated in G(0) with gamma-rays. | |
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MedLine Citation:
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PMID: 11682645 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report the occurrence of chromosome instability in human T lymphocytes irradiated in vitro with gamma-rays and cultured for several generations before analysis. The delayed effects of gamma-radiation have been evaluated by conventional and molecular (chromosome painting) cytogenetics in preparations obtained from long-term bulk cultures or clonal cultures. The results indicate that the cell progeny of gamma irradiated human T lymphocytes can be characterized by a higher rate of chromosome damage, but this effect depends on the individual donor response to ionizing radiation. Evidence has been collected about a differential involvement of chromosomes 7, 9 and 19 in the induced chromosome rearrangements, and this effect is equally visible as an immediate or delayed response of human T lymphocytes to ionizing radiation. |
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Authors:
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E Bortoletto; M Mognato; P Ferraro; S Canova; R Cherubini; L Celotti; A Russo |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Mutagenesis Volume: 16 ISSN: 0267-8357 ISO Abbreviation: Mutagenesis Publication Date: 2001 Nov |
Date Detail:
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Created Date: 2001-10-29 Completed Date: 2002-01-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8707812 Medline TA: Mutagenesis Country: England |
Other Details:
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Languages: eng Pagination: 529-37 Citation Subset: IM |
Affiliation:
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Department of Biology, University of Padova, Via U. Bassi 58/B, 35020 Legnaro, Padova, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cell Survival / genetics, radiation effects Cells, Cultured Chromosome Aberrations / radiation effects* Clone Cells / radiation effects Cytogenetic Analysis G0 Phase / genetics, radiation effects* Gamma Rays / adverse effects* Humans Male T-Lymphocytes / cytology, radiation effects* |
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