Document Detail

Chromosome imbalances in papillary renal cell carcinoma and first cytogenetic data of familial cases analyzed by comparative genomic hybridization.
MedLine Citation:
PMID:  8995481     Owner:  NLM     Status:  MEDLINE    
We used comparative genomic hybridization to analyze 17 tumor samples from 11 patients with papillary renal cell carcinoma (RCC), including three patients with hereditary papillary RCC. Whereas the most frequent aberrations confirmed data obtained by banding analyses, copy number increases on 5q, which previously were considered characteristic of nonpapillary RCC, were identified in two cases. In two complex cases belonging to the same family, a characteristic pattern of chromosomal aberrations was found: five of the six imbalances present in the less complex case were included in the karyotype of the other case, suggesting a genetically determined mechanism resulting in genomic instability of specific chromosomes or chromosomal subregions and/or selection of specific mutations.
M Bentz; U S Bergerheim; C Li; S Joos; C A Werner; M Baudis; J Gnarra; M J Merino; B Zbar; W M Linehan; P Lichter
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cytogenetics and cell genetics     Volume:  75     ISSN:  0301-0171     ISO Abbreviation:  Cytogenet. Cell Genet.     Publication Date:  1996  
Date Detail:
Created Date:  1997-01-30     Completed Date:  1997-01-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0367735     Medline TA:  Cytogenet Cell Genet     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  17-21     Citation Subset:  IM    
Deutsches Krebsforschungszentrum, Abt. Organisation komplexer Genome, Heidelberg, Germany.
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MeSH Terms
Aged, 80 and over
Carcinoma, Papillary / genetics*
Carcinoma, Renal Cell / genetics*
Chromosome Aberrations*
In Situ Hybridization, Fluorescence
Kidney Neoplasms / genetics*
Middle Aged
Tumor Cells, Cultured

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