Document Detail


Chromosome damage and early developmental arrest caused by the Rex element of Drosophila melanogaster.
MedLine Citation:
PMID:  7828823     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Rex (Ribosomal exchange) is a genetically identified repeated element within the ribosomal DNA (rDNA) of Drosophila melanogaster. Rex has a semidominant maternal effect that promotes exchange between and within rDNA arrays in the first few embryonic mitoses. Several of Rex's genetic properties suggest that its primary effect is rDNA-specific chromosome breakage that is resolved by recombination. We report here that rDNA crossovers are only a small, surviving minority of Rex-induced events. Cytology of embryos produced by Rex-homozygous females reveals obvious chromosome damage in at least a quarter of the embryos within the first three mitotic divisions. More than half of the embryos produced by Rex females die, and the developmental arrest is among the earliest reported for any maternal-effect lethal. The striking lethal phenotype suggests that embryos with early chromosome damage could be particularly fruitful subjects for analysis of the cell biology of early embryos.
Authors:
L G Robbins; S Pimpinelli
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Genetics     Volume:  138     ISSN:  0016-6731     ISO Abbreviation:  Genetics     Publication Date:  1994 Oct 
Date Detail:
Created Date:  1995-02-21     Completed Date:  1995-02-21     Revised Date:  2010-09-13    
Medline Journal Info:
Nlm Unique ID:  0374636     Medline TA:  Genetics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  401-11     Citation Subset:  IM    
Affiliation:
Genetics Program, Michigan State University, East Lansing 48824-1312.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Division
Crosses, Genetic
Crossing Over, Genetic
DNA Damage
DNA, Ribosomal / genetics*
Drosophila melanogaster / embryology,  genetics*
Embryo, Nonmammalian / cytology,  physiology*
Female
Genes, Insect
Genes, Lethal
Male
Mitosis
Grant Support
ID/Acronym/Agency:
1 FO6 TWO1657-01/TW/FIC NIH HHS
Chemical
Reg. No./Substance:
0/DNA, Ribosomal
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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