Document Detail

Chromosome cohesion, condensation, and separation.
MedLine Citation:
PMID:  10966455     Owner:  NLM     Status:  MEDLINE    
The faithful segregation of genetic information requires highly orchestrated changes of chromosome structure during the mitotic cell cycle. The linkage between duplicated sister DNAs is established during S phase and maintained throughout G2 phase (cohesion). In early mitosis, dramatic structural changes occur to produce metaphase chromosomes, each consisting of a pair of compacted sister chromatids (condensation). At anaphase onset, a signal is produced to disrupt the linkage between sister chromatids (separation), allowing them to be pulled apart to opposite poles of the cell. This review discusses our current understanding of the three stages of large-scale structural changes of chromosomes in eukaryotic cells. Recent genetic and biochemical studies have identified key components involved in these processes and started to uncover hitherto unexpected functional links between mitotic chromosome dynamics and other important chromosome functions.
T Hirano
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Annual review of biochemistry     Volume:  69     ISSN:  0066-4154     ISO Abbreviation:  Annu. Rev. Biochem.     Publication Date:  2000  
Date Detail:
Created Date:  2000-12-12     Completed Date:  2000-12-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  2985150R     Medline TA:  Annu Rev Biochem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  115-44     Citation Subset:  IM    
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.
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MeSH Terms
Adenosine Triphosphatases / physiology
Cell Cycle Proteins
Chromosomal Proteins, Non-Histone
Chromosomes / physiology*
DNA-Binding Proteins / physiology
Fungal Proteins
Genes, Fungal
Histones / physiology
Meiosis / physiology
Mitosis / physiology
Models, Biological
Multiprotein Complexes
Nuclear Proteins / physiology
Saccharomyces cerevisiae / cytology,  genetics,  physiology
Schizosaccharomyces / cytology,  genetics,  physiology
Grant Support
Reg. No./Substance:
0/Cell Cycle Proteins; 0/Chromosomal Proteins, Non-Histone; 0/DNA-Binding Proteins; 0/Fungal Proteins; 0/Histones; 0/Multiprotein Complexes; 0/Nuclear Proteins; 0/cohesins; 0/condensin complexes; EC 3.6.1.-/Adenosine Triphosphatases

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