Document Detail

Chromosome changes and benzene exposure. A review.
MedLine Citation:
PMID:  395589     Owner:  NLM     Status:  MEDLINE    
Benzene exposure can induce chromosome aberrations in somatic cells (lymphocytes and bone marrow cells) of man and of experimental animals in vivo, as well as in some in vitro systems. Numerical and structural chromosome changes in bone marrow cells have been described in subjects with benzene haemopathy. Increased rates of structural chromosomal aberrations both of the "unstable" and of the "stable" type in cultured peripheral blood lymphocytes have been observed not only in subjects with chronic benzene poisoning, but also in individuals with past benzene haemopathy and in subjects with past benzene exposure without signs of poisoning; these findings persisted for years or decades after cessation of exposure. In some cases of benzene-induced leukaemias the cytogenetic pattern was variable, as it is true also for the "spontaneous" acute leukaemias. The possible implications of the finding of chromosome damage from benzene to bone marrow cells for the occurence of leukaemias are discussed. The possibilities and limitations of cytogenetic studies in the biological monitoring of subjects exposed to benzene are commented on.
A Forni
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Reviews on environmental health     Volume:  3     ISSN:  0048-7554     ISO Abbreviation:  Rev Environ Health     Publication Date:  1979  
Date Detail:
Created Date:  1980-05-23     Completed Date:  1980-05-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0425754     Medline TA:  Rev Environ Health     Country:  ISRAEL    
Other Details:
Languages:  eng     Pagination:  5-17     Citation Subset:  IM    
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MeSH Terms
Benzene / adverse effects*
Bone Marrow / drug effects
Cell Cycle / drug effects*
Chromosome Aberrations*
Chromosomes / drug effects*
Environmental Exposure
Hela Cells / drug effects
Leukemia, Myeloid, Acute / chemically induced
Lymphocytes / drug effects
Metaphase / drug effects*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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