Document Detail

Chromosome breakage and cellular death are induced in oral epitelial cells of hairdressers: a preliminary study.
MedLine Citation:
PMID:  22901279     Owner:  NLM     Status:  Publisher    
Abstract The aim of the present study was comparatively evaluate genomic damage (micronucleus) and cellular death (pyknosis, karyolysis and karyorrhexis) in exfoliated oral mucosa cells from hairdressers using two different anatomic buccal sites: cheek mucosa and lateral border of the tongue. A total of 28 hairdressers and 30 health controls (non-exposed individuals) were included in this setting. Individuals had epithelial cells from cheek and lateral border of the tongue mechanically exfoliated, placed in fixative and dropped in clean slides which were checked for the above nuclear phenotypes. The results pointed out significant statistically differences (p<0.05) of micronucleated oral mucosa cells from hairdressers in the lateral border of the tongue. Exposure to hair dyes caused increase of other nuclear alterations closely related to cytotoxicity such as karrhyorexis, pyknosis and karyolysis in both oral sites evaluated. In summary, these data indicate that hairdressers are occupationally exposed to agents which are genotoxic and cytotoxic. It seems that lateral border of the tongue is more sensitive site to geno- and cytotoxic effects of hairdyes.
Viviane Carlin; Ana Carolina C Fracalossi; Sandra R Miranda; Juliana Noguti; Victor H Pereira da Silva; Celina T F Oshima; Daniel A Ribeiro
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-18
Journal Detail:
Title:  Toxicology mechanisms and methods     Volume:  -     ISSN:  1537-6524     ISO Abbreviation:  Toxicol. Mech. Methods     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101134521     Medline TA:  Toxicol Mech Methods     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Departamento de Biociencias, Universidade Federal de Sao Paulo, UNIFESP, Santos, SP, Brazil.
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