Document Detail


Chromosome analysis of nine osteosarcomas.
MedLine Citation:
PMID:  7513549     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although recurrent chromosome abnormalities have been identified in several histologic subtypes of sarcomas, no consistent rearrangement has yet been found in osteosarcomas. Cytogenetic analyses of nine cases of osteosarcoma are reported, including seven newly diagnosed tumors and two recurrent tumors. There were seven high-grade osteosarcomas, one periosteal osteosarcoma, and one well-differentiated sarcoma. All tumors were studied in short-term primary culture. Modal number ranged from near diploid to near triploid. Seven tumors had complex karyotypes with multiple structural abnormalities; two had only normal karyotypes. The retinoblastoma gene on chromosome 13 and the TP53 gene on chromosome 17 have been involved in osteosarcoma. Five tumors had loss of a whole copy of chromosome 13, and three of these also had a loss of a whole copy of chromosome 17. However, these losses were observed in the setting of numerous other chromosome losses. Numerous structural abnormalities were observed, many involving additions of unidentified material, unbalanced translocations, or deletions. Structural abnormalities with similar breakpoints involving 6q, 8q, 9q, and 14p were seen in two or three tumors each. When the tumors in this series were added to the 18 published cases, the pericentromeric regions of chromosomes 1, 3, and 14, and segments 6q15-21, 8q24, 9q34, 12p13, 17p13, and 19q13, were found to be involved in five or more structural rearrangements. Molecular analyses of these chromosome regions may yield genes important in the pathogenesis of osteosarcoma.
Authors:
W A Hoogerwerf; A L Hawkins; E J Perlman; C A Griffin
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Genes, chromosomes & cancer     Volume:  9     ISSN:  1045-2257     ISO Abbreviation:  Genes Chromosomes Cancer     Publication Date:  1994 Feb 
Date Detail:
Created Date:  1994-06-06     Completed Date:  1994-06-06     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9007329     Medline TA:  Genes Chromosomes Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  88-92     Citation Subset:  IM    
Affiliation:
Oncology Center, Johns Hopkins School of Medicine, Baltimore, Maryland 21287-8934.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aneuploidy*
Bone Neoplasms / genetics*,  mortality,  pathology
Brain Neoplasms / genetics,  radiotherapy
Child
Chromosome Aberrations*
Chromosome Deletion
Cranial Irradiation / adverse effects
Female
Hodgkin Disease / drug therapy,  genetics,  radiotherapy
Humans
Karyotyping
Lung Neoplasms / genetics,  secondary
Male
Neoplasms, Radiation-Induced / genetics
Neoplasms, Second Primary / genetics
Oncogenes
Osteosarcoma / genetics*,  mortality,  pathology,  secondary
Pineal Gland
Pinealoma / genetics,  radiotherapy
Survival Analysis
Grant Support
ID/Acronym/Agency:
2P30 CA06973-29/CA/NCI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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