| Chromosome analysis in hematologic disorders. The leukemias. | |
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MedLine Citation:
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PMID: 6587777 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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For two decades, cytogenetic studies have been used to rule in (or out) the Philadelphia (Ph1) chromosome associated with chronic myeloid leukemia. Beyond this single purpose, chromosome studies have generally not been utilized in or applied to the practice of hematology-oncology. This report presents male and female patients, teens to 70s in age, with representative hematologic disorders, in whom the cytogenetic findings were useful clinically. These cases illustrate the following principles: (1) hematologic disorders can be characterized by chromosome analysis; (2) chromosome findings help in the diagnosis, prognosis, and treatment of blood diseases; (3) blood and bone marrow samples can be processed routinely for cytogenetic analysis; (4) these samples can be transported long distances from clinic to laboratory; and (5) the contemporary practice of hematology and oncology requires chromosome analysis for fuller evaluation and understanding of hematologic conditions. |
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Authors:
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A A Sandberg; R Morgan; C Berger; B K Hecht; F Hecht |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The American journal of medicine Volume: 76 ISSN: 0002-9343 ISO Abbreviation: Am. J. Med. Publication Date: 1984 Jun |
Date Detail:
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Created Date: 1984-07-17 Completed Date: 1984-07-17 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0267200 Medline TA: Am J Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 971-82 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Bone Marrow / ultrastructure Chromosome Aberrations / genetics Chromosome Disorders Chromosomes, Human, 21-22 and Y* Chromosomes, Human, 6-12 and X* Female Hematocrit Humans Karyotyping Leukemia / genetics* Leukemia, Myeloid / genetics Leukemia, Myeloid, Acute / genetics Lymphoma / genetics Male Middle Aged Pancytopenia / genetics Translocation, Genetic* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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