Document Detail

Chromosome abnormalities in human embryos.
MedLine Citation:
PMID:  10098475     Owner:  NLM     Status:  MEDLINE    
The presence of numerical chromosome abnormalities in human embryos was studied using fluorescence in-situ hybridization with four or more chromosome-specific probes. When most cells of an embryo are analysed, this technique allows differentiation to be made between aneuploidy, mosaicism, haploidy and polyploidy. Abnormal types of fertilization, such as unipronucleated, tripronucleated zygotes and zygotes with uneven pronuclei, were studied using this technique. We have found a strong correlation between some types of dysmorphism with chromosomal abnormalities. In addition, the more impaired the development of an embryo, the more chromosomal abnormalities were detected in those embryos. Maternal age and other factors were linked to an increase in chromosome abnormalities (hormonal regimes, temperature changes), but not to intracytoplasmic sperm injection.
S Munné; J Cohen
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Human reproduction update     Volume:  4     ISSN:  1355-4786     ISO Abbreviation:  Hum. Reprod. Update     Publication Date:    1998 Nov-Dec
Date Detail:
Created Date:  1999-05-06     Completed Date:  1999-05-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9507614     Medline TA:  Hum Reprod Update     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  842-55     Citation Subset:  IM    
The Center for Reproductive Medicine and Science of Saint Barnabas Medical Center, New Jersey, USA.
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MeSH Terms
Cell Nucleus / ultrastructure
Chromosome Aberrations*
Cleavage Stage, Ovum
Embryo, Mammalian*
Embryonic and Fetal Development
Zygote / ultrastructure

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