Document Detail


Chromosome abnormalities in diffuse large B-cell lymphomas: analysis of 231 Chinese patients.
MedLine Citation:
PMID:  23135954     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Genome instability is a hallmark of cancer. Diffuse large B-cell lymphoma (DLBCL) is the most common form of non-Hodgkin lymphoma with high levels of chromosomal aberrations. The purpose of this study was to characterize chromosomal aberrations in Chinese DLBCL patients and to compare chromosomal abnormalities between germinal centre B-cell-like (GCB) and non-GCB subgroups. Fluorescence in situ hybridization, G-band cytogenetics and immunohistochemistry were performed in 231 cases of de novo DLBCL. We demonstrated that the rate of abnormal and complex karyotypes was 89.1% (139/156) and 92.8% (129/139), respectively. We found a total of 490 structural chromosomal aberrations, including 96 frequent and recurring structural alterations. Most importantly, we identified several rare or novel chromosomal alterations: eight gains (5, 13, 14q, 17, 19p, 20, 21p, Y), one loss (21) and three recurrent translocations [t(7;15)(q22;q22), t(3;20)(p24;q13.1), t(2;3)(q21;q25)]. Moreover, the frequent recurrent genomic imbalance between GCB and non-GCB subgroups was different. Finally, we discovered two cases of concurrent IGH-BCL6 and MYC rearrangements. The rate of abnormal karyotypes in DLBCL patients of Chinese descent was similar to that of Western countries, but some common karyotypes were different, as were the abnormal karyotypes of GCB and non-GCB subgroups. Our discovery of rare and novel abnormal karyotypes may represent unique chromosomal alterations in Chinese DLBCL patients. Copyright © 2012 John Wiley & Sons, Ltd.
Authors:
Xiaoli Zhao; Rong Fan; Guowei Lin; Xiaoqin Wang
Related Documents :
23505384 - Matefin/sun-1 phosphorylation is part of a surveillance mechanism to coordinate chromos...
6589604 - Genetic basis of male sterility in hybrids between two closely related species of droso...
23555294 - Mouse hfm1/mer3 is required for crossover formation and complete synapsis of homologous...
22924114 - The association between y chromosome microdeletion and recurrent pregnancy loss.
23505384 - Matefin/sun-1 phosphorylation is part of a surveillance mechanism to coordinate chromos...
11978964 - Intragenic breakpoint within rad51l1 in a t(6;14)(p21.3;q24) of a pulmonary chondroid h...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-8
Journal Detail:
Title:  Hematological oncology     Volume:  -     ISSN:  1099-1069     ISO Abbreviation:  Hematol Oncol     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8307268     Medline TA:  Hematol Oncol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 John Wiley & Sons, Ltd.
Affiliation:
Department of Haematology, Huashan Hospital of Fudan University, Shanghai, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Etiology of insulin resistance in youth with type 2 diabetes.
Next Document:  Chondrogenic differentiation of bone marrow concentrate grown onto a hylauronan scaffold: Rationale ...