Document Detail


Chromosome aberrations in uterine smooth muscle tumors: potential diagnostic relevance of cytogenetic instability.
MedLine Citation:
PMID:  2354458     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cytogenetic studies were carried out on a low-grade metastatic uterine leiomyosarcoma and on a large degenerating uterine leiomyoma. The leiomyosarcoma and leiomyoma were hyperdiploid and hypodiploid, respectively, and both tumors contained multiple consistent chromosome aberrations. In the patient with leiomyosarcoma, flow cytometric studies of proliferative foci from a previously resected uterine leiomyoma revealed near triploidy, suggesting that the leiomyosarcoma was metastatic from an unrecognized malignant uterine primary lesion. The leiomyosarcoma was characterized by extreme cytogenetic instability, whereas the leiomyoma demonstrated cytogenetic stability. The present cases and review of the literature on leiomyosarcomas and leiomyomas reveal cytogenetic instability to be very common in leiomyosarcomas (present in 8 of 10 cases) and uncommon in leiomyomas (present in 1 of 25 cases). A grading system is described which might be useful in evaluating the diagnostic and prognostic relevance of cytogenetic instability in uterine, and other, malignancies.
Authors:
J A Fletcher; C C Morton; K Pavelka; J M Lage
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Publication Detail:
Type:  Case Reports; Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cancer research     Volume:  50     ISSN:  0008-5472     ISO Abbreviation:  Cancer Res.     Publication Date:  1990 Jul 
Date Detail:
Created Date:  1990-07-23     Completed Date:  1990-07-23     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  2984705R     Medline TA:  Cancer Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  4092-7     Citation Subset:  IM    
Affiliation:
Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts 02115.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aneuploidy
Chromosome Aberrations*
Diploidy
Female
Flow Cytometry
Humans
Karyotyping
Leiomyoma / genetics*,  pathology
Leiomyosarcoma / genetics*,  pathology
Middle Aged
Muscle, Smooth*
Uterine Neoplasms / genetics*,  pathology
Grant Support
ID/Acronym/Agency:
AG00294/AG/NIA NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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