| Chromosome aberrations in uterine smooth muscle tumors: potential diagnostic relevance of cytogenetic instability. | |
| | |
MedLine Citation:
|
PMID: 2354458 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Cytogenetic studies were carried out on a low-grade metastatic uterine leiomyosarcoma and on a large degenerating uterine leiomyoma. The leiomyosarcoma and leiomyoma were hyperdiploid and hypodiploid, respectively, and both tumors contained multiple consistent chromosome aberrations. In the patient with leiomyosarcoma, flow cytometric studies of proliferative foci from a previously resected uterine leiomyoma revealed near triploidy, suggesting that the leiomyosarcoma was metastatic from an unrecognized malignant uterine primary lesion. The leiomyosarcoma was characterized by extreme cytogenetic instability, whereas the leiomyoma demonstrated cytogenetic stability. The present cases and review of the literature on leiomyosarcomas and leiomyomas reveal cytogenetic instability to be very common in leiomyosarcomas (present in 8 of 10 cases) and uncommon in leiomyomas (present in 1 of 25 cases). A grading system is described which might be useful in evaluating the diagnostic and prognostic relevance of cytogenetic instability in uterine, and other, malignancies. |
| | |
Authors:
|
J A Fletcher; C C Morton; K Pavelka; J M Lage |
Related Documents
:
|
7631688 - Massive congenital intracranial teratoma with skull rupture at delivery. 20549388 - Uterine leiomyosarcoma metastasis to the pancreas: report of a case and review of the l... 937968 - Leiomyosarcoma of the nasal cavity and paranasal sinuses. 16713128 - Intestinal adenocarcinoma arising in a mature cystic teratoma of the ovary: a case report. 1588678 - Poisoning of an urban family due to misapplication of household organophosphate and car... 14614978 - Prosthetic valve thrombosis-case report and literature review. |
Publication Detail:
|
Type: Case Reports; Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Cancer research Volume: 50 ISSN: 0008-5472 ISO Abbreviation: Cancer Res. Publication Date: 1990 Jul |
Date Detail:
|
Created Date: 1990-07-23 Completed Date: 1990-07-23 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 2984705R Medline TA: Cancer Res Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 4092-7 Citation Subset: IM |
Affiliation:
|
Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts 02115. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Aneuploidy Chromosome Aberrations* Diploidy Female Flow Cytometry Humans Karyotyping Leiomyoma / genetics*, pathology Leiomyosarcoma / genetics*, pathology Middle Aged Muscle, Smooth* Uterine Neoplasms / genetics*, pathology |
| Grant Support | |
ID/Acronym/Agency:
|
AG00294/AG/NIA NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Spontaneous prolactin transplantable tumor in the Wistar/Furth rat (SMtTW): a new animal model of hu...
Next Document: Cloning of estrogen-responsive messenger RNAs in the T-47D human breast cancer cell line.