Document Detail


The Chromosome Axis Controls Meiotic Events through a Hierarchical Assembly of HORMA Domain Proteins.
MedLine Citation:
PMID:  25446517     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Proteins of the HORMA domain family play central, but poorly understood, roles in chromosome organization and dynamics during meiosis. In Caenorhabditis elegans, four such proteins (HIM-3, HTP-1, HTP-2, and HTP-3) have distinct but overlapping functions. Through combined biochemical, structural, and in vivo analysis, we find that these proteins form hierarchical complexes through binding of their HORMA domains to cognate peptides within their partners' C-terminal tails, analogous to the "safety belt" binding mechanism of Mad2. These interactions are critical for recruitment of HIM-3, HTP-1, and HTP-2 to chromosome axes. HTP-3, in addition to recruiting the other HORMA domain proteins to the axis, plays an independent role in sister chromatid cohesion and double-strand break formation. Finally, we find that mammalian HORMAD1 binds a motif found both at its own C terminus and at that of HORMAD2, indicating that this mode of intermolecular association is a conserved feature of meiotic chromosome structure in eukaryotes.
Authors:
Yumi Kim; Scott C Rosenberg; Christine L Kugel; Nora Kostow; Ofer Rog; Vitaliy Davydov; Tiffany Y Su; Abby F Dernburg; Kevin D Corbett
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Publication Detail:
Type:  Journal Article     Date:  2014-11-06
Journal Detail:
Title:  Developmental cell     Volume:  31     ISSN:  1878-1551     ISO Abbreviation:  Dev. Cell     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-12-03     Completed Date:  -     Revised Date:  2014-12-05    
Medline Journal Info:
Nlm Unique ID:  101120028     Medline TA:  Dev Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  487-502     Citation Subset:  IM    
Copyright Information:
Copyright © 2014 Elsevier Inc. All rights reserved.
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Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
R01 GM065591/GM/NIGMS NIH HHS; R01 GM104141/GM/NIGMS NIH HHS

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