Document Detail


Chromosome 9p21 polymorphism is associated with myocardial infarction but not with clinical outcome in Han Chinese.
MedLine Citation:
PMID:  19548844     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: rs1333049 polymorphism on chromosome 9p21 has been shown to affect susceptibility to coronary artery disease (CAD) in Caucasians. This study examined the association of rs1333049 with myocardial infarction (MI), angiographic severity of CAD and clinical outcome after a first acute MI in Han Chinese. METHODS: rs1333049 polymorphism was genotyped in 520 patients with a first acute MI and in 560 controls. The number of angiographically documented diseased coronary arteries (luminal diameter stenosis > or = 50%), echocardiographic left ventricular ejection fraction (LVEF), and major adverse cardiac events (MACE) during follow-up (mean, 29+/-15 months) were recorded. RESULTS: Patients with MI had higher frequencies of the CC genotype (30.0% vs. 20.7%) or C allele (55.5% vs. 46.2%) compared with controls (all p<0.01). rs1333049 polymorphism was strongly associated with MI [odds ratio (OR) 1.48, 95% confidence interval (CI) 1.22-1.79] after adjusting for traditional risk factors. Although longer hospitalization stay was observed in patients with the rs1333049-C allele, this polymorphism was not related to angiographic severity of CAD, LVEF, and occurrence of MACE after MI. CONCLUSIONS: This study demonstrates an association of rs1333049 polymorphism locus on chromosome 9p21 with risk for MI, but not with post-MI prognosis in Han Chinese.
Authors:
Wen Hui Peng; Lin Lu; Qi Zhang; Rui Yan Zhang; Ling Jie Wang; Xiao Xiang Yan; Qiu Jing Chen; Wei Feng Shen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical chemistry and laboratory medicine : CCLM / FESCC     Volume:  47     ISSN:  1434-6621     ISO Abbreviation:  Clin. Chem. Lab. Med.     Publication Date:  2009  
Date Detail:
Created Date:  2009-07-31     Completed Date:  2009-10-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9806306     Medline TA:  Clin Chem Lab Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  917-22     Citation Subset:  IM    
Affiliation:
Department of Cardiology, Rui Jin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China.
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MeSH Terms
Descriptor/Qualifier:
Aged
Alleles
Asian Continental Ancestry Group / genetics*
China / epidemiology
Chromosomes, Human, Pair 9 / genetics*
Female
Gene Frequency / genetics*
Genetic Predisposition to Disease
Genotype
Humans
Kaplan-Meiers Estimate
Linkage Disequilibrium / genetics
Logistic Models
Male
Middle Aged
Multivariate Analysis
Myocardial Infarction / epidemiology,  genetics*,  mortality
Polymorphism, Single Nucleotide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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