Document Detail


Chromosome 17 polysomy in circulating tumor cells in patients with metastatic breast cancer: a case series.
MedLine Citation:
PMID:  21210173     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The human epidermal growth factor receptor 2 (HER2) gene is located on the long arm of chromosome 17 (Chr-17). While primary tumors with Chr-17 polysomy (polysomy 17) are histopathologically similar to HER2-negative tumors, the role of polysomy 17 in circulating tumor cells (CTCs) is still unknown. We report the detection rate of polysomy 17 in CTCs in patients with metastatic breast cancer (MBC). We determined the CTC count per 7.5 ml blood and polysomy 17 in CTCs at 3- to 4-week intervals up to 12 weeks in 52 patients. Polysomy was defined as Chr-17 ≥2.2. CTCs were detected in 40 of 52 patients (76.9%) during the study period, in 32 of the 52 patients (61.5%) at baseline, and in 21 of 49 patients (42.9%) at 3-4 weeks. Polysomy 17 in CTCs was present in 10 of 52 patients (19.2%) during the study period, in 5 of 52 patients (9.6%) at baseline, and in 7 of 49 patients (14.3%) at 3-4 weeks. The individual patient counts of polysomy 17 in CTCs/total count of CTCs examined for polysomy 17 at 3-4 weeks were 1/1, 1/7, 1/7, 2/27, 2/30, 2/50, and 3/50. Six of the 7 patients with polysomy 17 in CTCs had HER2-negative primary tumors. None of the CTCs displaying polysomy 17 themselves had HER2 amplification by FISH. In summary, polysomy 17 in CTCs was observed in only a small population of patients with MBC. We should prospectively evaluate its prognostic value in both HER2-positive and -negative metastatic breast cancer.
Authors:
Naoki Hayashi; Seigo Nakamura; Hiroshi Yagata; Yuji Shimoda; Hidekazu Ota; Gabriel N Hortobagyi; Massimo Cristofanilli; Naoto T Ueno
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-01-06
Journal Detail:
Title:  International journal of clinical oncology     Volume:  16     ISSN:  1437-7772     ISO Abbreviation:  Int. J. Clin. Oncol.     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-13     Completed Date:  2012-02-13     Revised Date:  2012-12-13    
Medline Journal Info:
Nlm Unique ID:  9616295     Medline TA:  Int J Clin Oncol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  596-600     Citation Subset:  IM    
Affiliation:
Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Breast Neoplasms / genetics*,  pathology*
Chromosome Aberrations*
Chromosomes, Human, Pair 17 / genetics*
Female
Humans
Middle Aged
Neoplasm Metastasis
Neoplastic Cells, Circulating / pathology*
Polyploidy
Receptor, erbB-2 / genetics*
Tumor Markers, Biological / genetics
Grant Support
ID/Acronym/Agency:
CA016672/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Tumor Markers, Biological; EC 2.7.10.1/ERBB2 protein, human; EC 2.7.10.1/Receptor, erbB-2

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