Document Detail


Chromosomal translocations and their role in the pathogenesis of non-Hodgkin's lymphomas.
MedLine Citation:
PMID:  12408337     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The discovery that non-Hodgkin's lymphomas are monoclonal and that recurrent chromosomal translocations are involved in their pathogenesis has greatly revolutionised their diagnosis and improved our understanding of these diseases. In the last decades, many genes deregulated by such recurrent chromosomal translocations have been identified. However, we have also learned that these genetic alterations are apparently insufficient, in themselves, to cause neoplastic cell transformation and that more complex genetic events must be involved. This review examines the involved genes in chromosomal translocations and current evidence and postulated mechanisms for their role in the pathogenesis of non-Hodgkin's lymphomas.
Authors:
Francisco Vega; Rocio Orduz; L Jeffrey Medeiros
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Pathology     Volume:  34     ISSN:  0031-3025     ISO Abbreviation:  Pathology     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-10-31     Completed Date:  2003-03-25     Revised Date:  2006-10-31    
Medline Journal Info:
Nlm Unique ID:  0175411     Medline TA:  Pathology     Country:  England    
Other Details:
Languages:  eng     Pagination:  397-409     Citation Subset:  IM    
Affiliation:
Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA.
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MeSH Terms
Descriptor/Qualifier:
Gene Expression*
Humans
Lymphoma, Non-Hodgkin / genetics*,  pathology
Molecular Biology*
Translocation, Genetic / genetics*

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