Document Detail

Chromosomal translocations activating myc sequences and transduction of v-abl are critical events in the rapid induction of plasmacytomas by pristane and abelson virus.
Jump to Full Text
MedLine Citation:
PMID:  6202819     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Plasmacytomas with short latent periods can be induced in BALB/c mice by a single intraperitoneal (i.p.) injection of 0.5 ml pristane followed 20-40 d later by an injection of Abelson virus. The karyotypes of 18 such tumors were determined; 10 of these had rcpt 12;15, 5 had rcpt 6;15 and 3 had no translocations, but two of these have been shown to have interstitial deletions of chromosome 15. The specific breakpoints were the same as described in pristane-induced plasmacytomas, i.e., at 15D2 /3, 6C2 , and 12F2 . Near diploid karyotypes and trisomy of chromosome 11 were frequently seen. All of the Abelson-plus-pristane-induced plasmacytomas (ABPC) were studied as transplanted tumors, contained integrated v- abl sequences, and actively transcribed v- abl mRNA. All but one of these tumors contained abundant myc RNA transcripts. The shortness of the latent periods of the ABPC suggests that the rcpt 12;15 and rcpt 6;15 occur soon after pristane administration and are present at the time Abelson virus is introduced. In this form of plasmacytomagenesis , activated v- abl genes appear to bypass other genetic changes that require a much longer period of time in pristane plasmacytomagenesis . Nonetheless, the consistent finding of chromosome-15 alterations and abundant myc expression in these plasmacytomas emphasize the apparent need for multiple events even in the genesis of some tumors induced by rapid transforming viruses.
Authors:
S Ohno; S Migita; F Wiener; M Babonits; G Klein; J F Mushinski; M Potter
Related Documents :
10379869 - Mapping of the breakpoints on the short arm of chromosome 17 in neoplasms with an i(17q).
2545339 - Amplification of the integrated viral transforming genes of human papillomavirus 18 and...
8389029 - Sublocalization of the synovial sarcoma-associated t(x;18) chromosomal breakpoint in xp...
10557049 - Molecular analysis of chromosomal breakpoints in three examples of chromosomal transloc...
2110029 - A murine plasmacytoma with a variant (15;16)(d2/3;b1) translocation that involves the c...
12110179 - Unrepaired dna breaks in p53-deficient cells lead to oncogenic gene amplification subse...
17488289 - The beach protein lvsb is localized on lysosomes and postlysosomes and limits their fus...
22311279 - Variation in concentrations of high-molecular-weight glutenin subunits and macropolymer...
17922479 - Understanding the accuracy of statistical haplotype inference with sequence data of kno...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of experimental medicine     Volume:  159     ISSN:  0022-1007     ISO Abbreviation:  J. Exp. Med.     Publication Date:  1984 Jun 
Date Detail:
Created Date:  1984-07-13     Completed Date:  1984-07-13     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985109R     Medline TA:  J Exp Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1762-77     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Abelson murine leukemia virus*
Animals
Carcinogens
Chromosome Aberrations
DNA, Viral / metabolism
Female
Karyotyping
Leukemia Virus, Murine*
Mice
Mice, Inbred BALB C
Nucleic Acid Hybridization
Oncogenes*
Plasmacytoma / etiology,  genetics*
RNA / metabolism
RNA, Viral / metabolism
Terpenes*
Transcription, Genetic
Translocation, Genetic*
Chemical
Reg. No./Substance:
0/Carcinogens; 0/DNA, Viral; 0/RNA, Viral; 0/Terpenes; 1921-70-6/pristane; 63231-63-0/RNA
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): J Exp Med
ISSN: 0022-1007
ISSN: 1540-9538
Publisher: The Rockefeller University Press
Article Information
Download PDF

Print publication date: Day: 1 Month: 6 Year: 1984
Volume: 159 Issue: 6
First Page: 1762 Last Page: 1777
ID: 2187320
Publisher Id: 84214795
PubMed Id: 6202819

Chromosomal translocations activating myc sequences and transduction of v-abl are critical events in the rapid induction of plasmacytomas by pristane and abelson virus


Article Categories:
  • Articles


Previous Document:  Molecular mechanism for feedback regulation of C4 biosynthesis in guinea pig peritoneal macrophage.
Next Document:  Evidence of HLA-DR antigen biosynthesis by human keratinocytes in disease.