Document Detail

Chromosomal numerical aberrations in oral lichen planus.
MedLine Citation:
PMID:  19493885     Owner:  NLM     Status:  MEDLINE    
The malignant potential of oral lichen planus (OLP) has been a matter of serious controversy. We aimed to detect chromosomal numerical aberrations in cells of brush samples collected from affected mucosa. The samples were simultaneously analyzed for morphology and fluorescent in situ hybridization (FISH) with chromosomes 2 and 8 centromeric probes. We analyzed 57 persons with OLP and 33 control individuals. A cut-off value of aneuploid cells was determined as 1.1%. Aneuploid cells were found in 16 persons with OLP (28.1%); in 10 individuals (17.5%), over 5% of the cells were aneuploid. Aneuploid cells were also detected in normal-looking mucosa of seven persons with OLP. One person with OLP developed squamous cell carcinoma; 10% of the cells examined were aneuploid. OLP carries an increased risk for chromosomal instability. Identifying aneuploid cells in a brush sample and the combined morphological and FISH analysis can increase the specificity in predicting the malignant potential of OLP.
N Yarom; T Shani; N Amariglio; S Taicher; I Kaplan; M Vered; G Rechavi; L Trakhtenbrot; A Hirshberg
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of dental research     Volume:  88     ISSN:  1544-0591     ISO Abbreviation:  J. Dent. Res.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-06-04     Completed Date:  2009-06-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0354343     Medline TA:  J Dent Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  427-32     Citation Subset:  D; IM    
Department of Oral and Maxillofacial Surgery, The Chaim Sheba Medical Center, Tel Hashomer, Israel.
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MeSH Terms
Aged, 80 and over
Carcinoma, Squamous Cell / pathology
Cell Shape
Cell Transformation, Neoplastic / pathology
Centromere / genetics
Chromosomal Instability / genetics
Chromosome Aberrations*
Chromosomes, Human, Pair 2 / genetics
Chromosomes, Human, Pair 8 / genetics
Chromosomes, Human, Pair 9 / genetics
Cytodiagnosis / instrumentation
Follow-Up Studies
In Situ Hybridization, Fluorescence
Lichen Planus, Oral / genetics*,  pathology
Middle Aged
Mouth Mucosa / pathology
Mouth Neoplasms / pathology
Tongue / pathology
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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