Document Detail


Chromosomal mapping of quantitative trait loci that influence renal hemodynamic functions.
MedLine Citation:
PMID:  10545438     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND:Impaired renal hemodynamic function has been suspected to be responsible for hypertension in the spontaneously hypertensive rat (SHR). METHODS AND RESULTS:We measured renal hemodynamic functions, including the glomerular filtration rate, renal plasma flow, and renal vascular resistance, in an F2 rat population derived from spontaneously hypertensive and Wistar-Kyoto (WKY) rats and performed a genome-wide screening to map quantitative trait loci that influence these functions to gain insight into the relationship between renal hemodynamic functions and blood pressure control. The D1 Mit7 locus was identified as a major locus that influenced renal hemodynamic functions, and we transferred the SHR chromosomal segment around the D1 Mit7 locus into the WKY strain. The congenic rats exhibited impaired renal hemodynamic functions. The systolic blood pressure of the congenic rats was significantly higher than that of age-matched WKY rats, but only at nighttime. No significant differences in systolic blood pressure during daytime or diastolic blood pressure were observed between the 2 strains. CONCLUSIONS: We have identified a chromosome segment that influences renal hemodynamic function. The SHR chromosome segment around the D1 Mit7 locus had significant, but not dramatic, effects in increasing blood pressure in the WKY genetic background. However, further studies will be necessary to determine the significance of this locus in SHR hypertension.
Authors:
N Iwai; M Kinoshita; H Shimoike
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Circulation     Volume:  100     ISSN:  1524-4539     ISO Abbreviation:  Circulation     Publication Date:  1999 Nov 
Date Detail:
Created Date:  1999-11-18     Completed Date:  1999-11-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1923-9     Citation Subset:  AIM; IM    
Affiliation:
Research Institute, National Cardiovascular Center, Osaka, Japan. niwai@res.ncvc.go.jp
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MeSH Terms
Descriptor/Qualifier:
Animals
Chromosome Mapping
Genetic Markers
Hemodynamics / physiology*
Hypertension / genetics*
Male
Phenotype
Quantitative Trait, Heritable*
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Renal Circulation / physiology*
Chemical
Reg. No./Substance:
0/Genetic Markers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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