Document Detail

Chromosomal locations of major tRNA gene clusters of Xenopus laevis.
MedLine Citation:
PMID:  8522270     Owner:  NLM     Status:  MEDLINE    
In Xenopus laevis eight tRNA genes are located in a 3.18 kb tandemly repeated unit. There are 150 copies of the unit at a single locus near the long arm telomere of one of the acrocentric chromosomes in the 14-17 group. Two additional classes of tRNA gene-containing repeats have been isolated (defined by clones p3.1 and p3.2) that have structures related to that of the 3.18 kb unit. Using in situ hybridization at the electron microscopic level, the p3.2 repeats are found clustered at a single locus in the subtelomeric region on one of the submetacentric chromosomes, whereas the p3.1 repeats are clustered at a locus indistinguishable from that containing the 3.18 kb repeats. This suggests that these tDNA tandem repeats can diverge in sequence from each other without being at distantly separated loci.
S Narayanswami; J L Doering; F J Fokta; D S Rosenthal; T N Nguyen; B A Hamkalo
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Chromosoma     Volume:  104     ISSN:  0009-5915     ISO Abbreviation:  Chromosoma     Publication Date:  1995 Oct 
Date Detail:
Created Date:  1995-12-06     Completed Date:  1995-12-06     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  2985138R     Medline TA:  Chromosoma     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  68-74     Citation Subset:  IM    
The Jackson Laboratory, 600 Main Street, Bar Harbor, ME Q4609, USA.
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MeSH Terms
Chromosome Mapping
In Situ Hybridization
Multigene Family
RNA, Transfer / genetics*
Repetitive Sequences, Nucleic Acid
Restriction Mapping
Xenopus laevis / genetics*
Grant Support
Reg. No./Substance:
9014-25-9/RNA, Transfer

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