| Chromosomal localization of human genes governing the interferon-induced antiviral state. | |
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MedLine Citation:
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PMID: 1059098 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Interferon sensitivity of different normal and aneusomic human cells and of different mouse-human hybrids cells has been compared. G21 trisomic cells are more sensitive than diploid cells; whereas, on the contrary, triploid cells are normal in their human interferon sensitivity. Among other aneusomic cell lines tested, E16 trisomic cells are significantly less sensitive. These data are in favor of the hypotheses that the G21 chromosome carries genetic information for structural proteins involved in the receptor system for interferon, that there is a regulatory mechanism governing the antiviral state, and that the E16 chromosome is a possible candidate for carrying information for such a depressive regulatory mechanism. None of the chromosome abnormalities studies are involved with interferon synthesis. |
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Authors:
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C Chany; M Vignal; P Couillin; N Van Cong; J Boué; A Boué |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 72 ISSN: 0027-8424 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 1975 Aug |
Date Detail:
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Created Date: 1976-01-16 Completed Date: 1976-01-16 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 3129-33 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Line Chromosomes / metabolism* Diploidy Dose-Response Relationship, Drug Genes* Hybrid Cells / drug effects, metabolism Interferons / metabolism*, pharmacology Karyotyping Trisomy Viral Interference |
| Chemical | |
Reg. No./Substance:
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9008-11-1/Interferons |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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