Document Detail

Chromosomal localization of human genes governing the interferon-induced antiviral state.
MedLine Citation:
PMID:  1059098     Owner:  NLM     Status:  MEDLINE    
Interferon sensitivity of different normal and aneusomic human cells and of different mouse-human hybrids cells has been compared. G21 trisomic cells are more sensitive than diploid cells; whereas, on the contrary, triploid cells are normal in their human interferon sensitivity. Among other aneusomic cell lines tested, E16 trisomic cells are significantly less sensitive. These data are in favor of the hypotheses that the G21 chromosome carries genetic information for structural proteins involved in the receptor system for interferon, that there is a regulatory mechanism governing the antiviral state, and that the E16 chromosome is a possible candidate for carrying information for such a depressive regulatory mechanism. None of the chromosome abnormalities studies are involved with interferon synthesis.
C Chany; M Vignal; P Couillin; N Van Cong; J Boué; A Boué
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  72     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1975 Aug 
Date Detail:
Created Date:  1976-01-16     Completed Date:  1976-01-16     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3129-33     Citation Subset:  IM    
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MeSH Terms
Cell Line
Chromosomes / metabolism*
Dose-Response Relationship, Drug
Hybrid Cells / drug effects,  metabolism
Interferons / metabolism*,  pharmacology
Viral Interference
Reg. No./Substance:

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