Document Detail


Chromosomal localization of the human gene encoding the 51-kDa subunit of mitochondrial complex I (NDUFV1) to 11q13.
MedLine Citation:
PMID:  8288251     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The 51-kDa flavoprotein subunit of mitochondrial NADH:ubiquinone oxidoreductase (Complex I) [NADH dehydrogenase (ubiquinone), flavoprotein 1 (51 kDa); EC 1.6.5.3] plays an important role in the formation of the NADH-binding site and is believed to be the principal site of entry for electrons donated by NADH into the respiratory chain. Human cDNA fragments of the 51-kDa protein were generated by polymerase chain reaction and used to localize the gene (NDUFV1) for this subunit to 11q13 by two separate techniques. This region of the human genome is strongly implicated in a number of different forms of cancer.
Authors:
S T Ali; A M Duncan; K Schappert; H H Heng; L C Tsui; W Chow; B H Robinson
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Genomics     Volume:  18     ISSN:  0888-7543     ISO Abbreviation:  Genomics     Publication Date:  1993 Nov 
Date Detail:
Created Date:  1994-02-22     Completed Date:  1994-02-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8800135     Medline TA:  Genomics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  435-9     Citation Subset:  IM    
Affiliation:
Department of Genetics, University of Toronto, Ontario, Canada.
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Base Sequence
Chromosome Mapping
Chromosomes, Human, Pair 11*
Cloning, Molecular
DNA
Electron Transport Complex I
Humans
In Situ Hybridization
Mitochondria / enzymology*
Molecular Sequence Data
NADH, NADPH Oxidoreductases / genetics*
Polymerase Chain Reaction
Chemical
Reg. No./Substance:
9007-49-2/DNA; EC 1.6.-/NADH, NADPH Oxidoreductases; EC 1.6.5.3/Electron Transport Complex I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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