Document Detail

Chromosomal localization of an SH2-containing tyrosine phosphatase (PTPN6).
MedLine Citation:
PMID:  1639416     Owner:  NLM     Status:  MEDLINE    
We have used panels of somatic cell hybrids and fluorescent in situ hybridization to determine the chromosomal localization of the novel nontransmembrane tyrosine phosphatase PTPN6 (protein tyrosine phosphatase, nonreceptor type 6), which contains two SH2 domains. PTPN6 maps to 12p13, a region commonly involved in leukemia-associated chromosomal abnormalities. Since PTPN6 is expressed at high levels in hematopoietic cells of all lineages and its expression is induced early in hematopoietic differentiation, altered expression and/or structure of PTPN6 may play a role in leukemogenesis.
J Plutzky; B G Neel; R D Rosenberg; R L Eddy; M G Byers; S Jani-Sait; T B Shows
Related Documents :
8401586 - Chromosomal distribution of 320 genes from a brain cdna library.
2767686 - Localization of the gene for uridine monophosphate synthase to human chromosome region ...
1733856 - Assignment of the gene encoding dna ligase i to human chromosome 19q13.2-13.3.
8643996 - Mapping of the p2u purinergic receptor gene to human chromosome 11q 13.5-14.1.
12115036 - A radiation hybrid map for the bovine y chromosome.
22132826 - Meiotic abnormalities underlying pollen sterility in wild potato hybrids and spontaneou...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Genomics     Volume:  13     ISSN:  0888-7543     ISO Abbreviation:  Genomics     Publication Date:  1992 Jul 
Date Detail:
Created Date:  1992-08-28     Completed Date:  1992-08-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8800135     Medline TA:  Genomics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  869-72     Citation Subset:  IM    
Molecular Medicine Unit, Beth Israel Hospital, Boston, Massachusetts 02215.
Data Bank Information
Bank Name/Acc. No.:
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Amino Acid Sequence
Base Sequence
Chromosome Mapping
Chromosomes, Human, Pair 12*
DNA / genetics
Hybrid Cells
Molecular Sequence Data
Nucleic Acid Hybridization
Protein Tyrosine Phosphatases / chemistry,  genetics*
Sulfhydryl Compounds / chemistry
Grant Support
Reg. No./Substance:
0/Sulfhydryl Compounds; 9007-49-2/DNA; EC Tyrosine Phosphatases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Sequence of the human factor VIII-associated gene is conserved in mouse.
Next Document:  Expressed sequence tags and chromosomal localization of cDNA clones from a subtracted retinal pigmen...