Document Detail


Chromosomal localization of an SH2-containing tyrosine phosphatase (PTPN6).
MedLine Citation:
PMID:  1639416     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have used panels of somatic cell hybrids and fluorescent in situ hybridization to determine the chromosomal localization of the novel nontransmembrane tyrosine phosphatase PTPN6 (protein tyrosine phosphatase, nonreceptor type 6), which contains two SH2 domains. PTPN6 maps to 12p13, a region commonly involved in leukemia-associated chromosomal abnormalities. Since PTPN6 is expressed at high levels in hematopoietic cells of all lineages and its expression is induced early in hematopoietic differentiation, altered expression and/or structure of PTPN6 may play a role in leukemogenesis.
Authors:
J Plutzky; B G Neel; R D Rosenberg; R L Eddy; M G Byers; S Jani-Sait; T B Shows
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Genomics     Volume:  13     ISSN:  0888-7543     ISO Abbreviation:  Genomics     Publication Date:  1992 Jul 
Date Detail:
Created Date:  1992-08-28     Completed Date:  1992-08-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8800135     Medline TA:  Genomics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  869-72     Citation Subset:  IM    
Affiliation:
Molecular Medicine Unit, Beth Israel Hospital, Boston, Massachusetts 02215.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/M77273
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Base Sequence
Chromosome Mapping
Chromosomes, Human, Pair 12*
DNA / genetics
Humans
Hybrid Cells
Molecular Sequence Data
Nucleic Acid Hybridization
Protein Tyrosine Phosphatases / chemistry,  genetics*
Sulfhydryl Compounds / chemistry
Grant Support
ID/Acronym/Agency:
HD05196/HD/NICHD NIH HHS; HG00333/HG/NHGRI NIH HHS; R-01-CA 49152/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Sulfhydryl Compounds; 9007-49-2/DNA; EC 3.1.3.48/Protein Tyrosine Phosphatases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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