Document Detail

Chromosomal imbalances in papillary renal cell carcinoma: genetic differences between histological subtypes.
MedLine Citation:
PMID:  9811338     Owner:  NLM     Status:  MEDLINE    
Papillary renal-cell carcinoma (RCC) is a renal carcinoma variant with distinct gross, microscopic, and cytogenetic features. Recently, a type 1 (pale cytoplasm, small-cell) and a type 2 (eosinophilic cytoplasm, large-cell) subtype of papillary RCC have been described. Chromosomal alterations associated with these tumor types were examined in 25 papillary RCCs by comparative genomic hybridization. Relative copy number gains were frequently detected at chromosomes 7p (56%), 7q (44%), 12q (28%), 16q (32%), 17p (56%), 17q (76%), and 20q (32%). Chromosomal regions that were most often lost included 1p (24%), 4q (36%), 6q (40%), 9p (36%), 13q (36%), Xp (28%), Xq (36%), and Y (73%). There were clinical and genetic differences between the subtypes of papillary RCC. Type 2 tumors were of higher nuclear grade (P = 0.0012) and higher stage (P = 0.01) and had a worse prognosis (P = 0.03) than type 1 tumors. The number of DNA gains per tumor, especially gains of 7p and 17p, was significantly higher in type 1 than in type 2 tumors (P < 0.01). These data suggest the existence of two distinct morphological and genetic subgroups of papillary RCC. Losses of chromosome Xp were associated with short patient survival (P < 0.01). Despite the small number of cases, this finding suggests that a gene on chromosome Xp may contribute to papillary RCC progression.
F Jiang; J Richter; P Schraml; L Bubendorf; T Gasser; G Sauter; M J Mihatsch; H Moch
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of pathology     Volume:  153     ISSN:  0002-9440     ISO Abbreviation:  Am. J. Pathol.     Publication Date:  1998 Nov 
Date Detail:
Created Date:  1998-11-25     Completed Date:  1998-11-25     Revised Date:  2013-06-11    
Medline Journal Info:
Nlm Unique ID:  0370502     Medline TA:  Am J Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1467-73     Citation Subset:  AIM; IM    
Institute of Pathology, University of Basel, Switzerland.
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MeSH Terms
Carcinoma, Papillary / genetics*,  pathology
Carcinoma, Renal Cell / genetics*,  pathology
Chromosome Aberrations*
Chromosome Banding
Disease-Free Survival
Gene Dosage
Image Processing, Computer-Assisted
In Situ Hybridization / methods
Kidney Neoplasms / genetics*,  pathology
Sequence Deletion
X Chromosome

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