Document Detail


Chromosomal imbalances in lung adenocarcinomas with or without mutations in the epidermal growth factor receptor gene.
MedLine Citation:
PMID:  20409020     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND OBJECTIVE: Epidermal growth factor receptor (EGFR) mutations are common in lung adenocarcinomas of Asian patients, implying a good response to treatment with the EGFR tyrosine kinase inhibitors, gefitinib and erlotinib. However, the distinct chromosomal imbalances between lung adenocarcinomas with and those without EGFR mutations have not been fully elucidated. METHODS: Seventy-seven patients of surgically resected lung adenocarcinoma were analysed for the EGFR exon 19 deletion and the L858R mutation, using mutant-enriched PCR, and for chromosomal imbalance alterations using comparative genomic hybridization. RESULTS: EGFR mutations were detected in 42 (54.5%) patients, including 22 with the exon 19 deletion and 20 with the L858R mutation. The mean number of chromosomal arms with imbalance alterations was significantly higher in tumours with EGFR mutations than in those lacking these two mutations. The minimal regions with gain on 1q23-q31, 6p12-p21.1 and 7q11.2, and loss on 3p21, 8p22-p23, 9q33, 10q25 and 13q13, differed significantly between lung adenocarcinomas with or without EGFR mutations. However, neither EGFR mutations, nor any of the common chromosomal imbalance alterations alone, exhibited significant associations with tumour stage or disease-specific survival of the patients. CONCLUSIONS: These results indicate that imbalance alterations at several chromosomal regions occur significantly more frequently in lung adenocarcinomas with EGFR mutations than in those without such mutations. Tumour growth-related genes in these chromosomal regions should be further investigated to improve our understanding of the common genetic alterations in lung adenocarcinomas with EGFR mutations.
Authors:
Yao Fong; Yue-Shan Lin; Chiou-Ping Liou; Chien-Fen Li; Ching-Cherng Tzeng
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-03-29
Journal Detail:
Title:  Respirology (Carlton, Vic.)     Volume:  15     ISSN:  1440-1843     ISO Abbreviation:  Respirology     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-06-15     Completed Date:  2010-09-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9616368     Medline TA:  Respirology     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  700-5     Citation Subset:  IM    
Affiliation:
Division of Thoracic Surgery, Department of Surgery, Chi Mei Medical Center, Tainan, Taiwan.
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / genetics*
Adult
Aged
Aged, 80 and over
Carcinoma, Non-Small-Cell Lung / genetics*
Chromosome Aberrations*
Humans
Lung Neoplasms / genetics*
Male
Middle Aged
Mutation*
Receptor, Epidermal Growth Factor / genetics*
Retrospective Studies
Chemical
Reg. No./Substance:
EC 2.7.10.1/Receptor, Epidermal Growth Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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