Document Detail

Chromosomal histone modification patterns--from conservation to diversity.
MedLine Citation:
PMID:  16546438     Owner:  NLM     Status:  MEDLINE    
The organization of DNA into chromatin regulates expression and maintenance (replication, repair, recombination, segregation) of genetic information in a dynamic manner. The N-terminal tails of the nucleosomal core histones are subjected to post-translational modifications such as acetylation, methylation, phosphorylation, ubiquitination, glycosylation, ADP-ribosylation, carbonylation and sumoylation. These modifications, together with DNA methylation, control the folding of the nucleosomal array into higher order structures and mediate signalling for cellular processes. Although histones and their modifications are highly conserved, recent data show that chromosomal distribution of individual modifications (acetylation, methylation, phosphorylation) can differ along the cell cycle as well as among and between groups of eukaryotes. This implies the possibility of evolutionary divergence in reading the "histone code".
Jörg Fuchs; Dmitri Demidov; Andreas Houben; Ingo Schubert
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2006-03-20
Journal Detail:
Title:  Trends in plant science     Volume:  11     ISSN:  1360-1385     ISO Abbreviation:  Trends Plant Sci.     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-04-24     Completed Date:  2006-06-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9890299     Medline TA:  Trends Plant Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  199-208     Citation Subset:  IM    
Leibniz-Institute of Plant Genetics and Crop Plant Research, Corrensstrasse 3, D-06466 Gatersleben, Germany.
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MeSH Terms
Arabidopsis / genetics,  metabolism,  ultrastructure
Cell Nucleus Division
Chromatin Assembly and Disassembly
DNA Methylation
Evolution, Molecular*
Histone Code*
Histones / metabolism*
Hordeum / genetics,  metabolism,  ultrastructure
Vicia faba / genetics,  metabolism,  ultrastructure
Reg. No./Substance:
Erratum In:
Trends Plant Sci. 2006 May;11(5):212

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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