Document Detail


Chromosomal duplication is a transient evolutionary solution to stress.
MedLine Citation:
PMID:  23197825     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Aneuploidy, an abnormal number of chromosomes, is a widespread phenomenon found in unicellulars such as yeast, as well as in plants and in mammalians, especially in cancer. Aneuploidy is a genome-scale aberration that imposes a severe burden on the cell, yet under stressful conditions specific aneuploidies confer a selective advantage. This dual nature of aneuploidy raises the question of whether it can serve as a stable and sustainable evolutionary adaptation. To clarify this, we conducted a set of laboratory evolution experiments in yeast and followed the long-term dynamics of aneuploidy under diverse conditions. Here we show that chromosomal duplications are first acquired as a crude solution to stress, yet only as transient solutions that are eliminated and replaced by more efficient solutions obtained at the individual gene level. These transient dynamics of aneuploidy were repeatedly observed in our laboratory evolution experiments; chromosomal duplications gained under stress were eliminated not only when the stress was relieved, but even if it persisted. Furthermore, when stress was applied gradually rather than abruptly, alternative solutions appear to have emerged, but not aneuploidy. Our findings indicate that chromosomal duplication is a first evolutionary line of defense, that retains survivability under strong and abrupt selective pressures, yet it merely serves as a "quick fix," whereas more refined and sustainable solutions take over. Thus, in the perspective of genome evolution trajectory, aneuploidy is a useful yet short-lived intermediate that facilitates further adaptation.
Authors:
Avihu H Yona; Yair S Manor; Rebecca H Herbst; Gal H Romano; Amir Mitchell; Martin Kupiec; Yitzhak Pilpel; Orna Dahan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-11-29
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  109     ISSN:  1091-6490     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-19     Completed Date:  2013-02-28     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  21010-5     Citation Subset:  IM    
Affiliation:
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel.
Data Bank Information
Bank Name/Acc. No.:
GEO/GSE40817
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MeSH Terms
Descriptor/Qualifier:
Aneuploidy*
Biological Evolution
Chromosome Duplication*
Chromosome Mapping
Chromosomes / ultrastructure*
Environment
Evolution, Molecular
Fungal Proteins / genetics
Genes, Fungal
Haploidy
Heat-Shock Proteins / genetics
Hot Temperature
Hydrogen-Ion Concentration
Models, Genetic
Neoplasms / genetics*
Oligonucleotide Array Sequence Analysis
Phenotype
Saccharomyces cerevisiae / genetics*
Temperature
Chemical
Reg. No./Substance:
0/Fungal Proteins; 0/Heat-Shock Proteins
Comments/Corrections

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