Document Detail


Chromosomal distribution of 320 genes from a brain cDNA library.
MedLine Citation:
PMID:  8401586     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have determined the chromosomal assignment of 320 brain expressed genes by studying the segregation of polymerase chain reaction (PCR) products in human rodent somatic cell hybrids and by genetically mapping polymorphic cDNAs using the CEPH (Centre d'Etude du Polymophisme Humaine) reference pedigrees and database. These mapped genes can function as markers on the physical map of the human genome, as well as serve as candidate disease gene loci. Distribution of these genes to the human chromosomes correlates well with the GC content of the chromosomes. However, the distribution of these genes does not correlate well with the cytogenetic length of each chromosome.
Authors:
M H Polymeropoulos; H Xiao; J M Sikela; M Adams; J C Venter; C R Merril
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Nature genetics     Volume:  4     ISSN:  1061-4036     ISO Abbreviation:  Nat. Genet.     Publication Date:  1993 Aug 
Date Detail:
Created Date:  1993-11-05     Completed Date:  1993-11-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9216904     Medline TA:  Nat Genet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  381-6     Citation Subset:  IM    
Affiliation:
Laboratory of Biochemical Genetics, National Institute of Mental Health, Neuroscience Center at St. Elizabeths, Washington, DC 20032.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / metabolism*
Chromosome Mapping*
Chromosomes, Human*
Cloning, Molecular
DNA, Complementary / chemistry,  genetics*
Humans
Hybrid Cells
Information Systems
Lod Score
Polymerase Chain Reaction / methods
Polymorphism, Genetic
Chemical
Reg. No./Substance:
0/DNA, Complementary

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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