Document Detail

Chromosomal assignment of human cytochrome P-450 (debrisoquine/sparteine type) to chromosome 22.
MedLine Citation:
PMID:  3472585     Owner:  NLM     Status:  MEDLINE    
In order to determine on which chromosome the gene controlling human cytochrome P-450 (debrisoquine/sparteine type) is located a linkage study of polymorphic sparteine oxidation (PSO) to various polymorphic markers was carried out. Positive information for linkage between PSO and the P1 blood group was obtained with a maximal LOD-score of LOD = 3.35 for both male and female recombination fraction estimates of theta m = theta f = 0.0. The P1 blood group has been recently mapped to the long arm of chromosome 22. Thus it can be concluded that the gene controlling human cytochrome P-450 (debrisoquine/sparteine) is situated on the long arm of chromosome 22 in close vicinity to P1.
M Eichelbaum; M P Baur; H J Dengler; B O Osikowska-Evers; G Tieves; C Zekorn; C Rittner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of clinical pharmacology     Volume:  23     ISSN:  0306-5251     ISO Abbreviation:  Br J Clin Pharmacol     Publication Date:  1987 Apr 
Date Detail:
Created Date:  1987-07-08     Completed Date:  1987-07-08     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7503323     Medline TA:  Br J Clin Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  455-8     Citation Subset:  IM    
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MeSH Terms
Chromosome Mapping
Chromosomes, Human, Pair 22*
Cytochrome P-450 Enzyme System / genetics*
Debrisoquin / metabolism
Gene Frequency
Genetic Markers
Linkage (Genetics)*
P Blood-Group System / genetics
Sparteine / metabolism
Reg. No./Substance:
0/Genetic Markers; 0/P Blood-Group System; 1131-64-2/Debrisoquin; 90-39-1/Sparteine; 9035-51-2/Cytochrome P-450 Enzyme System

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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