| Chromosomal abnormalities in T-cell large granular lymphocyte leukaemia: report of two cases and review of the literature. | |
| | |
MedLine Citation:
|
PMID: 11849217 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Cytogenetic information on T-cell large granular lymphocyte leukaemia (T-LGL; large granular lymphocytosis) is limited. We report two cases of T-LGL with unusual karyotypic aberrations. The first case showed a novel inv(7)(p15q22) as the sole chromosomal abnormality, while the second case showed an inv(14)(q11q32) with evidence of clonal evolution. The breakpoints 7p14-p15 and 14q11 coincide with the T-cell receptor (TCR)-gamma and TCR-alpha/TCR-delta gene loci respectively. This is the first report describing the possible involvement of T-cell receptor genes in karyotypic aberrations in T-LGL. |
| | |
Authors:
|
K F Wong; J C W Chan; H S Y Liu; C Man; Y L Kwong |
Related Documents
:
|
3319677 - Primary splenic hairy cell leukaemia: a case report and review of the literature. 16800267 - Mucinous adenocarcinoma arising from the gastrointestinal epithelium in benign cystic t... 9781657 - Correlation of proliferation indices, apoptosis, and related oncogene expression (bcl-2... 11560157 - Clinicohistopathologic comparison of adult type and juvenile type xanthogranulomas in k... 17521107 - Illness in a redeployed soldier. 19874337 - Therapeutic options for palmoplantar pustulosis. |
Publication Detail:
|
Type: Case Reports; Journal Article; Review |
Journal Detail:
|
Title: British journal of haematology Volume: 116 ISSN: 0007-1048 ISO Abbreviation: Br. J. Haematol. Publication Date: 2002 Mar |
Date Detail:
|
Created Date: 2002-03-07 Completed Date: 2002-04-08 Revised Date: 2005-11-16 |
Medline Journal Info:
|
Nlm Unique ID: 0372544 Medline TA: Br J Haematol Country: England |
Other Details:
|
Languages: eng Pagination: 598-600 Citation Subset: IM |
Affiliation:
|
Department of Pathology, Queen Elizabeth Hospital, Hong Kong SAR, China. kfwong@ha.org.hk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Chromosome Aberrations* Chromosomes, Human, Pair 14 / genetics Chromosomes, Human, Pair 7 / genetics Female Humans Karyotyping Leukemia, T-Cell / genetics* Middle Aged Receptors, Antigen, T-Cell, alpha-beta / genetics Receptors, Antigen, T-Cell, gamma-delta / genetics |
| Chemical | |
Reg. No./Substance:
|
0/Receptors, Antigen, T-Cell, alpha-beta; 0/Receptors, Antigen, T-Cell, gamma-delta |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Severe decrease in peripheral blood dendritic cells in hairy cell leukaemia.
Next Document: Identification of a novel WT1-derived peptide which induces human leucocyte antigen-A24-restricted a...