Document Detail


Chromosomal abnormalities in T-cell large granular lymphocyte leukaemia: report of two cases and review of the literature.
MedLine Citation:
PMID:  11849217     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cytogenetic information on T-cell large granular lymphocyte leukaemia (T-LGL; large granular lymphocytosis) is limited. We report two cases of T-LGL with unusual karyotypic aberrations. The first case showed a novel inv(7)(p15q22) as the sole chromosomal abnormality, while the second case showed an inv(14)(q11q32) with evidence of clonal evolution. The breakpoints 7p14-p15 and 14q11 coincide with the T-cell receptor (TCR)-gamma and TCR-alpha/TCR-delta gene loci respectively. This is the first report describing the possible involvement of T-cell receptor genes in karyotypic aberrations in T-LGL.
Authors:
K F Wong; J C W Chan; H S Y Liu; C Man; Y L Kwong
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  British journal of haematology     Volume:  116     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-03-07     Completed Date:  2002-04-08     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  England    
Other Details:
Languages:  eng     Pagination:  598-600     Citation Subset:  IM    
Affiliation:
Department of Pathology, Queen Elizabeth Hospital, Hong Kong SAR, China. kfwong@ha.org.hk
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MeSH Terms
Descriptor/Qualifier:
Adult
Chromosome Aberrations*
Chromosomes, Human, Pair 14 / genetics
Chromosomes, Human, Pair 7 / genetics
Female
Humans
Karyotyping
Leukemia, T-Cell / genetics*
Middle Aged
Receptors, Antigen, T-Cell, alpha-beta / genetics
Receptors, Antigen, T-Cell, gamma-delta / genetics
Chemical
Reg. No./Substance:
0/Receptors, Antigen, T-Cell, alpha-beta; 0/Receptors, Antigen, T-Cell, gamma-delta

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