Document Detail


Chromosomal abnormalities and birth defects among couples with colchicine treated familial Mediterranean fever.
MedLine Citation:
PMID:  16202748     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine whether colchicine prescribed for familial Mediterranean fever is teratogenic. STUDY DESIGN: Reproductive histories were analyzed from 326 couples referred for prenatal diagnosis because 1 partner was affected. Numbers of chromosomal abnormalities and birth defects were compared with numbers expected from published rates. RESULTS: There were 901 pregnancies, and amniocentesis had been performed in 566, all but 3 conceived while taking colchicine. Seven numerical chromosomal abnormalities were found, not statistically significantly greater than the 4.99 expected from maternal age and gestation of diagnosis (P = .24): unbalanced structural abnormalities were 6, compared with 3.22 expected (P = .11). There were 7 birth defects, a considerably lower rate than reported in local malformation registers. CONCLUSION: The current policy of routine amniocentesis in pregnancies of couples taking colchicine should not be changed until sufficient data accumulates to establish whether the higher number of chromosomal anomalies in this group is significant.
Authors:
Michal Berkenstadt; Boaz Weisz; Howard Cuckle; Michal Di-Castro; Esther Guetta; Gad Barkai
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  193     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-10-05     Completed Date:  2006-01-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1513-6     Citation Subset:  AIM; IM    
Affiliation:
Danek Gertner Institute of Human Genetics, Sheba Medical Center, Tel Hashomer, Israel. mberken@sheba.health.gov.il
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MeSH Terms
Descriptor/Qualifier:
Abnormalities, Drug-Induced / epidemiology*,  etiology*
Adult
Chromosome Aberrations / chemically induced*,  statistics & numerical data*
Colchicine / adverse effects*
Familial Mediterranean Fever / drug therapy*
Female
Humans
Male
Pregnancy
Prenatal Exposure Delayed Effects / chemically induced*,  epidemiology*
Chemical
Reg. No./Substance:
64-86-8/Colchicine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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