| Chromosomal aberrations induced by the restriction endonucleases EcoR I, Pst I, Sal I and Bam HI in CHO cells. | |
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MedLine Citation:
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PMID: 3041204 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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4 widely used cohesive end-producing restriction endonucleases (REs), EcoR I, Pst I, Sal I and Bam HI were tested in CHO cells for their aberration-inducing effects. It was demonstrated that all these REs significantly increased the frequencies of aberrant cells, the aberration frequencies per cell and the aberration frequencies per chromosome. The effects of REs on chromosomal aberrations are similar to ionizing radiation, but more minutes and interchange figures are observed. Polyploid cells are more susceptible to RE treatment, an interesting finding which may be explained by the mechanisms leading to the formation of polyploid cells. |
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Authors:
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S Z Zhang; W F Dong |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Mutation research Volume: 180 ISSN: 0027-5107 ISO Abbreviation: Mutat. Res. Publication Date: 1987 Sep |
Date Detail:
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Created Date: 1987-10-06 Completed Date: 1987-10-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0400763 Medline TA: Mutat Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 109-14 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Line Chromosome Aberrations* Cricetinae DNA Restriction Enzymes / metabolism* Interphase Polyploidy Ring Chromosomes Sister Chromatid Exchange |
| Chemical | |
Reg. No./Substance:
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EC 3.1.21.-/DNA Restriction Enzymes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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