Document Detail


Chromosomal aberrations in peripheral lymphocytes of children as biomarkers of environmental exposure and life style.
MedLine Citation:
PMID:  12191864     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The original purpose of our study was to determine if the detection of chromosomal aberrations in peripheral lymphocytes of children might be used as a biomarker of environmental pollution and life style. We compared the results of cytogenetic analyses performed in children and adolescents in the periods 1984-1993 and 1994-1999, in a total of 3402 subjects. The frequency of aberrant cells (AB.C.) markedly decreased in the period 1994-1999 compared with the period 1984-1993. The decreases in AB.C. were significant in the age groups 7-15 and 16-19 years: 1.63% AB.C. versus 1.14% AB.C. and 2.02% AB.C. versus 1.08% AB.C., respectively (P<0.01). No difference in the frequency of AB.C. was observed in newborns. Based on our experience, we believe that monitoring the spontaneous level of chromosomal aberrations in children over 5 year periods may be used to examine the general changes in environmental pollution in larger geographic areas.
Authors:
P Rössner; H Bavorova; D Ocadlikova; E Svandova; R J Sram
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Toxicology letters     Volume:  134     ISSN:  0378-4274     ISO Abbreviation:  Toxicol. Lett.     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-08-22     Completed Date:  2002-10-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7709027     Medline TA:  Toxicol Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  79-85     Citation Subset:  IM    
Affiliation:
Laboratory of Genetic Toxicology, National Institute of Public Health, Prague, Czech Republic. pavel.rossner@szu.cz
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Biological Markers
Cells, Cultured
Child
Child, Preschool
Chromosome Aberrations*
Cytogenetic Analysis
Czech Republic
Environmental Exposure / adverse effects*,  analysis
Environmental Monitoring / methods*
Female
Humans
Life Style*
Lymphocyte Activation
Lymphocytes / chemistry,  drug effects*,  immunology
Male
Metals, Heavy / analysis
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Metals, Heavy

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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