Document Detail

Chromosomal integration and location on IncT plasmids of the blaCTX-M-2 gene in Proteus mirabilis clinical isolates.
MedLine Citation:
PMID:  22106217     Owner:  NLM     Status:  MEDLINE    
Analysis of five CTX-M-2-producing Proteus mirabilis isolates in Japan demonstrated that bla(CTX-M-2) was located on the chromosome in four isolates and on IncT plasmids in three isolates, including two isolates that also carried the gene on the chromosome. In all four isolates with chromosomal bla(CTX-M-2), ISEcp1 was responsible for the integration of the gene into the chromosome. Three different sites in the P. mirabilis genomic sequence were utilized as integration sites.
Sohei Harada; Yoshikazu Ishii; Tomoo Saga; Yuichi Kouyama; Kazuhiro Tateda; Keizo Yamaguchi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-11-21
Journal Detail:
Title:  Antimicrobial agents and chemotherapy     Volume:  56     ISSN:  1098-6596     ISO Abbreviation:  Antimicrob. Agents Chemother.     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-23     Completed Date:  2012-05-25     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  0315061     Medline TA:  Antimicrob Agents Chemother     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1093-6     Citation Subset:  IM    
Department of Microbiology and Infectious Diseases, School of Medicine, Faculty of Medicine, Toho University, Tokyo, Japan.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/AB543698;  AB543699;  AB543700;  AB543701
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MeSH Terms
Anti-Bacterial Agents / pharmacology
Chromosomes, Bacterial / genetics*
Conjugation, Genetic / genetics*
DNA, Bacterial / genetics
Drug Resistance, Bacterial
Electrophoresis, Gel, Pulsed-Field
Japan / epidemiology
Microbial Sensitivity Tests
Molecular Sequence Data
Plasmids / genetics*
Proteus Infections / epidemiology,  microbiology
Proteus mirabilis / drug effects,  enzymology,  genetics*,  isolation & purification
Sequence Analysis, DNA
beta-Lactamases / genetics*
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/DNA, Bacterial; EC 3.5.2.-/beta-lactamase CTX-2; EC

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