Document Detail

Chromomeres revisited.
MedLine Citation:
PMID:  22956230     Owner:  NLM     Status:  Publisher    
The history of studies on the chromomeres of lampbrush chromosomes is outlined and evidence for the nature and function of these structures is collected and summarised. Chromomeres and their associated loops on lampbrush chromosomes are not genetic units although in some special cases, they consist of specific families of repeated DNA sequences. The emergence of a chromomeric organisation coincides with the onset and intensification of transcription on lampbrush loops. Modern molecular studies have provided evidence that the chromatin of lampbrush chromomeres differs in several important respects from that of condensed metaphase chromosomes. It is in a highly dynamic state that facilitates localised transcription whilst keeping the chromosome safe from structural changes that might impede its orderly progression up to and through meiotic metaphase 1. Lampbrush chromosomes (LBCs) are a physically induced phenomenon, facilitated by the selective absence of molecular factors that would interfere with their main transcriptional role. LBC morphology is highly dynamic and driven by transcriptive activity.
Herbert C Macgregor
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-7
Journal Detail:
Title:  Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology     Volume:  -     ISSN:  1573-6849     ISO Abbreviation:  Chromosome Res.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9313452     Medline TA:  Chromosome Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
School of Biosciences, University of Exeter, Exeter, EX4 4SB, UK,
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