| Chromogranin A: a surprising link between granule biogenesis and hypertension. | |
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MedLine Citation:
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PMID: 16007250 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chromogranin A (CHGA) and its derived peptides, which are stored and released from dense-core secretory granules of neuroendocrine cells, have been implicated as playing multiple roles in the endocrine, cardiovascular, and nervous systems. In this issue of the JCI, Mahapatra et al. present in vivo evidence for 2 important functions of CHGA: the regulation of catecholamine-containing dense-core chromaffin granule biogenesis in the adrenal gland and the control of blood pressure. Obliteration of CHGA expression in a KO mouse model led to decreased size and number of chromaffin granules as well as hypertension in these animals. Transgenic expression of human Chga and exogenous injection of human catestatin, a CHGA-derived nicotinic cholinergic antagonist, restored normal blood pressure in these mice. These results suggest a coupled relationship between CHGA-mediated chromaffin granule biogenesis, necessary for catecholamine storage, and catestatin-induced inhibition of cholinergic-stimulated catecholamine release, which regulates autonomic control of blood pressure. |
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Authors:
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Taeyoon Kim; Y Peng Loh |
Publication Detail:
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Type: Comment; Journal Article; Review |
Journal Detail:
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Title: The Journal of clinical investigation Volume: 115 ISSN: 0021-9738 ISO Abbreviation: J. Clin. Invest. Publication Date: 2005 Jul |
Date Detail:
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Created Date: 2005-07-11 Completed Date: 2005-08-31 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7802877 Medline TA: J Clin Invest Country: United States |
Other Details:
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Languages: eng Pagination: 1711-3 Citation Subset: AIM; IM |
Affiliation:
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Section on Cellular Neurobiology, National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects Catecholamines / physiology Chromaffin Granules / physiology* Chromogranin A Chromogranins / genetics, pharmacology, physiology* Humans Hypertension / etiology*, genetics, physiopathology Mice Mice, Knockout Mice, Transgenic Models, Biological Peptide Fragments / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/CHGA protein, human; 0/Catecholamines; 0/Chromogranin A; 0/Chromogranins; 0/Peptide Fragments; 0/chromogranin A (344-364); 0/chromogranin A, mouse |
| Comments/Corrections | |
Comment On:
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J Clin Invest. 2005 Jul;115(7):1942-52
[PMID:
16007257
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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