Document Detail

Chromogranin A: a surprising link between granule biogenesis and hypertension.
MedLine Citation:
PMID:  16007250     Owner:  NLM     Status:  MEDLINE    
Chromogranin A (CHGA) and its derived peptides, which are stored and released from dense-core secretory granules of neuroendocrine cells, have been implicated as playing multiple roles in the endocrine, cardiovascular, and nervous systems. In this issue of the JCI, Mahapatra et al. present in vivo evidence for 2 important functions of CHGA: the regulation of catecholamine-containing dense-core chromaffin granule biogenesis in the adrenal gland and the control of blood pressure. Obliteration of CHGA expression in a KO mouse model led to decreased size and number of chromaffin granules as well as hypertension in these animals. Transgenic expression of human Chga and exogenous injection of human catestatin, a CHGA-derived nicotinic cholinergic antagonist, restored normal blood pressure in these mice. These results suggest a coupled relationship between CHGA-mediated chromaffin granule biogenesis, necessary for catecholamine storage, and catestatin-induced inhibition of cholinergic-stimulated catecholamine release, which regulates autonomic control of blood pressure.
Taeyoon Kim; Y Peng Loh
Publication Detail:
Type:  Comment; Journal Article; Review    
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  115     ISSN:  0021-9738     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-07-11     Completed Date:  2005-08-31     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1711-3     Citation Subset:  AIM; IM    
Section on Cellular Neurobiology, National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892, USA.
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MeSH Terms
Blood Pressure / drug effects
Catecholamines / physiology
Chromaffin Granules / physiology*
Chromogranin A
Chromogranins / genetics,  pharmacology,  physiology*
Hypertension / etiology*,  genetics,  physiopathology
Mice, Knockout
Mice, Transgenic
Models, Biological
Peptide Fragments / pharmacology
Reg. No./Substance:
0/CHGA protein, human; 0/Catecholamines; 0/Chromogranin A; 0/Chromogranins; 0/Peptide Fragments; 0/chromogranin A (344-364); 0/chromogranin A, mouse
Comment On:
J Clin Invest. 2005 Jul;115(7):1942-52   [PMID:  16007257 ]

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