Document Detail


Chromogranin A: a novel factor acting at the cross road between the neuroendocrine and the cardiovascular systems.
MedLine Citation:
PMID:  21178786     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Chromogranin A (CHGA) is a secretory protein stored in and released from neurons and cells of the diffuse neuroendocrine system. Cells of the adrenal medulla and adrenergic terminals are a main source of CHGA but also myocardial cells produce it under stress conditions. After secretion, CHGA is cleaved into several biologically active fragments, including vasostatins and catestatin. CHGA and its proteolytic peptides exert a broad spectrum of activities on the cardiovascular system. They act on blood pressure by controlling the vascular tone and the cardiac inotropic and chronotropic function. CHGA revealed to be a sensitive marker of myocardial dysfunction, with a high predictive power of morbidity and mortality in heart failure and ischemic heart disease. In addition, CHGA has been involved in the control of sustained endothelial inflammation and has been shown to be a good marker of persistent vascular inflammation in rheumatologic disorders affecting vessels.
Authors:
Gabriele Di Comite; Alberto Morganti
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of hypertension     Volume:  29     ISSN:  1473-5598     ISO Abbreviation:  J. Hypertens.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-14     Completed Date:  2011-06-16     Revised Date:  2011-08-29    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  409-14     Citation Subset:  IM    
Affiliation:
Department of Immunology, National Institute of Neuroscience, 4-1-1 Ogawahigashi, Kodaira, Tokyo, Japan. gdicomite@ncnp.go.jp
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure*
Chromogranin A / blood,  physiology*
Endothelium, Vascular / physiology
Heart Rate*
Humans
Hypertension / diagnosis
Neurosecretory Systems / physiology*
Vasculitis / etiology
Chemical
Reg. No./Substance:
0/Chromogranin A
Comments/Corrections
Comment In:
J Hypertens. 2011 Aug;29(8):1662   [PMID:  21750441 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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