| Chromogranin A: a novel factor acting at the cross road between the neuroendocrine and the cardiovascular systems. | |
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MedLine Citation:
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PMID: 21178786 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chromogranin A (CHGA) is a secretory protein stored in and released from neurons and cells of the diffuse neuroendocrine system. Cells of the adrenal medulla and adrenergic terminals are a main source of CHGA but also myocardial cells produce it under stress conditions. After secretion, CHGA is cleaved into several biologically active fragments, including vasostatins and catestatin. CHGA and its proteolytic peptides exert a broad spectrum of activities on the cardiovascular system. They act on blood pressure by controlling the vascular tone and the cardiac inotropic and chronotropic function. CHGA revealed to be a sensitive marker of myocardial dysfunction, with a high predictive power of morbidity and mortality in heart failure and ischemic heart disease. In addition, CHGA has been involved in the control of sustained endothelial inflammation and has been shown to be a good marker of persistent vascular inflammation in rheumatologic disorders affecting vessels. |
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Authors:
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Gabriele Di Comite; Alberto Morganti |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of hypertension Volume: 29 ISSN: 1473-5598 ISO Abbreviation: J. Hypertens. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-14 Completed Date: 2011-06-16 Revised Date: 2011-08-29 |
Medline Journal Info:
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Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: England |
Other Details:
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Languages: eng Pagination: 409-14 Citation Subset: IM |
Affiliation:
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Department of Immunology, National Institute of Neuroscience, 4-1-1 Ogawahigashi, Kodaira, Tokyo, Japan. gdicomite@ncnp.go.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure* Chromogranin A / blood, physiology* Endothelium, Vascular / physiology Heart Rate* Humans Hypertension / diagnosis Neurosecretory Systems / physiology* Vasculitis / etiology |
| Chemical | |
Reg. No./Substance:
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0/Chromogranin A |
| Comments/Corrections | |
Comment In:
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J Hypertens. 2011 Aug;29(8):1662
[PMID:
21750441
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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