Document Detail


Chromogranin A, a member of neuroendocrine secretory proteins as a selective marker for laboratory diagnosis of pheochromocytoma.
MedLine Citation:
PMID:  18271679     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The function of chromogranin A (CGA) is reviewed, and the radioimmunometric determination of plasma CGA was evaluated as a marker of pheochromocytoma using a comparison of pheochromocytoma patients immediately before surgery (group P, n=25, 635+/-451 ng/ml) with other groups of patients, i.e. pheochromocytoma patients approximately 1 year after removal of tumor (group PP, n=13, 69+/-33 ng/ml), medullary thyroid carcinoma patients (group M, n= 22, 106+/-59 ng/ml), congenital adrenal hyperplasy patients (n=33, 65+/-40 ng/ml), and controls (n=31, 66+/-29 ng/ml). A CGA level above cut off value 130 ng/ml was found in 24 of 25 patients in group P, 1 (relapse) of 13 patients in group PP, and 4 of 22 patients in group M. In the group P we found a significant association between the size of the tumors removed and plasma CGA concentrations (p=0.0016), and also a significant (p=0.0016) relationship between plasma CGA concentrations and PASS score rating the malignity of pheochromocytoma. We can conclude that plasma CGA concentration as determined by radioimmunometric assay (which is simple without the necessity of special laboratory equipment) is an effective marker of pheochromocytoma with association to malignity and tumor mass.
Authors:
R Bílek; L Safarík; V Ciprová; P Vlcek; L Lisá
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-02-13
Journal Detail:
Title:  Physiological research / Academia Scientiarum Bohemoslovaca     Volume:  57 Suppl 1     ISSN:  0862-8408     ISO Abbreviation:  Physiol Res     Publication Date:  2008  
Date Detail:
Created Date:  2008-06-13     Completed Date:  2008-09-15     Revised Date:  2008-10-28    
Medline Journal Info:
Nlm Unique ID:  9112413     Medline TA:  Physiol Res     Country:  Czech Republic    
Other Details:
Languages:  eng     Pagination:  S171-9     Citation Subset:  IM    
Affiliation:
Institute of Endocrinology, Prague, Czech Republic. rbilek@endo.cz
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MeSH Terms
Descriptor/Qualifier:
Adrenal Gland Neoplasms / blood*,  diagnosis*,  surgery
Adrenal Hyperplasia, Congenital / blood
Adult
Aged
Amino Acid Sequence
Carcinoma, Medullary / blood
Chromogranin A / blood*,  genetics
Female
Humans
Male
Middle Aged
Molecular Sequence Data
Multiple Endocrine Neoplasia / blood
Pheochromocytoma / blood*,  diagnosis*,  surgery
Radioimmunoassay
Thyroid Neoplasms / blood
Tumor Markers, Biological / blood*,  genetics
Chemical
Reg. No./Substance:
0/Chromogranin A; 0/Tumor Markers, Biological

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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