| Chromogranin A (CgA)--the influence of various factors in vivo and in vitro, and existing disorders on it's concentration in blood. | |
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MedLine Citation:
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PMID: 20806183 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chromogranin A (CgA) is regarded as a major, nonspecific neuroendocrine tumour (NET) marker. The results of CgA blood concentration, however, may actually be influenced by various factors or coexisting pathological conditions. Among the factors causing a substantial increase of the blood CgA concentration are: treatment with proton-pump inhibitors or H₂-receptor blockers, chronic atrophic gastritis (type A), impaired renal function, prostate cancer and BPH, and rheumatoid arthritis with high level of RF IgM. In addition, the sort of investigated biological material (whether it is serum or plasma) is of importance. There are also many conditions which may have a moderate or little influence on the concentration of CgA, among them are: inflammatory bowel disease (ulcerative colitis and Crohn's disease), deteriorating liver function, untreated essential hypertension, heart failure, hypercortisolism, pregnancy, and, in some subjects, ingestion of a meal. Proper assessment of the CgA results requires detailed knowledge about various factors, drugs, and pathological conditions influencing its concentration in blood. |
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Authors:
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Piotr Glinicki; Wojciech Jeske |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Endokrynologia Polska Volume: 61 ISSN: 0423-104X ISO Abbreviation: Endokrynol Pol Publication Date: 2010 Jul-Aug |
Date Detail:
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Created Date: 2010-08-31 Completed Date: 2011-01-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370674 Medline TA: Endokrynol Pol Country: Poland |
Other Details:
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Languages: eng Pagination: 384-7 Citation Subset: IM |
Affiliation:
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Department of Endocrinology, The Medical Centre of Postgraduate Education, Warsaw, Poland. piotr.glinicki@wp.pl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Chromogranin A
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blood* Chronic Disease Eating / physiology Female Gastritis, Atrophic / blood Histamine H2 Antagonists / pharmacology Humans Hypertension / blood Inflammatory Bowel Diseases / blood Kidney Diseases / blood Male Pregnancy / blood* Prostatic Hyperplasia / blood Prostatic Neoplasms / blood Proton Pump Inhibitors / pharmacology Tumor Markers, Biological / blood* |
| Chemical | |
Reg. No./Substance:
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0/Chromogranin A; 0/Histamine H2 Antagonists; 0/Proton Pump Inhibitors; 0/Tumor Markers, Biological |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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