Document Detail


Chromobility: the rapid movement of chromosomes in interphase nuclei.
MedLine Citation:
PMID:  22103519     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
There are an increasing number of studies reporting the movement of gene loci and whole chromosomes to new compartments within interphase nuclei. Some of the movements can be rapid, with relocation of parts of the genome within less than 15 min over a number of microns. Some of these studies have also revealed that the activity of motor proteins such as actin and myosin are responsible for these long-range movements of chromatin. Within the nuclear biology field, there remains some controversy over the presence of an active nuclear acto-myosin motor in interphase nuclei. However, both actin and myosin isoforms are localized to the nucleus, and there is a requirement for rapid and directed movements of genes and whole chromosomes and evidence for the involvement of motor proteins in this relocation. The presence of nuclear motors for chromatin movement is thus an important and timely debate to have.
Authors:
Joanna M Bridger
Related Documents :
21248739 - Alk2 mutation in a patient with down's syndrome and a congenital heart defect.
6404119 - Cyclic leukocytosis and long survival in chronic myeloid leukemia.
3101039 - Breakpoint distribution in variant philadelphia translocations in chronic myeloid leuke...
6940519 - Meningeal involvement in philadelphia chromosome-negative chronic granulocytic leukemia.
269009 - Quantification by dna-based cytophotometry of the 9q+/22q-chromosomal translocation ass...
6204679 - Sudan black b positive acute lymphoblastic leukaemia.
2211179 - The high resolution g- and r-banding pattern in chromosomes of river buffalo (bubalus b...
18369449 - The mating-type chromosome in the filamentous ascomycete neurospora tetrasperma represe...
10706359 - Ring chromosome 22 and autism: report and review.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biochemical Society transactions     Volume:  39     ISSN:  1470-8752     ISO Abbreviation:  Biochem. Soc. Trans.     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-11-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7506897     Medline TA:  Biochem Soc Trans     Country:  England    
Other Details:
Languages:  eng     Pagination:  1747-51     Citation Subset:  IM    
Affiliation:
Laboratory of Nuclear and Genomic Health, Centre of Cell and Chromosome Biology, Biosciences, School of Health Sciences and Social Care, Brunel University, Uxbridge, London UB8 3PH, U.K.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Nuclear envelope influences on cell-cycle progression.
Next Document:  LMNA-linked lipodystrophies: from altered fat distribution to cellular alterations.