| Chromium(III)-insulin derivatives and their implication in glucose metabolism. | |
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MedLine Citation:
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PMID: 2649639 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Insulin has been reacted with five chromium(III) complexes that are capable of relatively facile substitution of aquo ligands. The new Cr(III) insulin derivatives have been characterized by means of electronic and infrared spectra, and evidence for major changes in the protein structure, including the state of aggregation, has been presented. Supporting evidence for the arguments favoring the beneficiary role of chromium(III) in glucose metabolism has been obtained using in vivo studies, and it has been shown that insulin derived with Cr(salen) (H2O)2+ is capable of reversing the blood sugar, serum cholesterol, and phospholipids levels to those of normal rats. The results emphasize the dependence of biopotency on the structure of Cr(III) complexes used for derivation of insulin and discount the postulates that Cr(III) serves to assemble insulin and receptor units through metal-sulphur bonding. The influence of Cr(III) on the structural stability and state of aggregation of insulin and their possible role in glucose metabolism is discussed. |
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Authors:
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K Govindaraju; T Ramasami; D Ramaswamy |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of inorganic biochemistry Volume: 35 ISSN: 0162-0134 ISO Abbreviation: J. Inorg. Biochem. Publication Date: 1989 Feb |
Date Detail:
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Created Date: 1989-05-22 Completed Date: 1989-05-22 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7905788 Medline TA: J Inorg Biochem Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 137-47 Citation Subset: IM |
Affiliation:
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Central Leather Research Institute, Adyar, Madras, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Glucose / metabolism Cholesterol / blood Chromium / pharmacology, therapeutic use* Diabetes Mellitus, Experimental / blood, drug therapy* Insulin / analogs & derivatives*, pharmacology, therapeutic use* Male Phospholipids / blood Protein Binding Rats Reference Values Spectrophotometry, Infrared |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Phospholipids; 11061-68-0/Insulin; 57-88-5/Cholesterol; 7440-47-3/Chromium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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