Document Detail


Chromium(III)-insulin derivatives and their implication in glucose metabolism.
MedLine Citation:
PMID:  2649639     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Insulin has been reacted with five chromium(III) complexes that are capable of relatively facile substitution of aquo ligands. The new Cr(III) insulin derivatives have been characterized by means of electronic and infrared spectra, and evidence for major changes in the protein structure, including the state of aggregation, has been presented. Supporting evidence for the arguments favoring the beneficiary role of chromium(III) in glucose metabolism has been obtained using in vivo studies, and it has been shown that insulin derived with Cr(salen) (H2O)2+ is capable of reversing the blood sugar, serum cholesterol, and phospholipids levels to those of normal rats. The results emphasize the dependence of biopotency on the structure of Cr(III) complexes used for derivation of insulin and discount the postulates that Cr(III) serves to assemble insulin and receptor units through metal-sulphur bonding. The influence of Cr(III) on the structural stability and state of aggregation of insulin and their possible role in glucose metabolism is discussed.
Authors:
K Govindaraju; T Ramasami; D Ramaswamy
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of inorganic biochemistry     Volume:  35     ISSN:  0162-0134     ISO Abbreviation:  J. Inorg. Biochem.     Publication Date:  1989 Feb 
Date Detail:
Created Date:  1989-05-22     Completed Date:  1989-05-22     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7905788     Medline TA:  J Inorg Biochem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  137-47     Citation Subset:  IM    
Affiliation:
Central Leather Research Institute, Adyar, Madras, India.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Glucose / metabolism
Cholesterol / blood
Chromium / pharmacology,  therapeutic use*
Diabetes Mellitus, Experimental / blood,  drug therapy*
Insulin / analogs & derivatives*,  pharmacology,  therapeutic use*
Male
Phospholipids / blood
Protein Binding
Rats
Reference Values
Spectrophotometry, Infrared
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Phospholipids; 11061-68-0/Insulin; 57-88-5/Cholesterol; 7440-47-3/Chromium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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