| Chromium, Selenium, and Zinc Multimineral Enriched Yeast Supplementation Ameliorates Diabetes Symptom in Streptozocin-Induced Mice. | |
| | |
MedLine Citation:
|
PMID: 22081404 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Chromium, selenium, and zinc malnutrition has been implicated in the pathogenesis of diabetic mellitus. This study aims to investigate the effects of novel multiminerals-enriched yeast (MMEY) which are minerals supplementation containing elevated levels of chromium, selenium, and zinc simultaneously in a diabetic animal model. Streptozocin-induced diabetic male Balb/c mice (n = 80) were randomly divided into diabetes control group and three treatment groups. They were administrated oral gavages with low, medium, or high doses of MMEY, respectively. Meanwhile, healthy male Balb/c mice (n = 40) of the same body weight were randomly assigned into normal control group and high dose of MMEY control group. After 8 weeks duration of treatment, the animals were sacrificed by cervical dislocation. Serum glucose concentrations, lipid profiles, oxidative/antioxidant, and immunity status were determined. No significant adverse effects were observed in the high-dose MMEY control group. Treatment of the diabetic mice with medium- or high-dose MMEY significantly decreased serum glucose, triglyceride, total cholesterol, and malondialdehyde and increased high-density lipoprotein cholesterol, glutathione, and the activities of superoxide dismutase and glutathione peroxidase. In addition, MMEY ameliorated the pathological damage of the pancreatic islets, elevated the thymus or spleen coefficient, and increased the expressions of interleukin-2 and -4 in spleen lymphocytes compared with unsupplemented diabetic mice. In conclusion, these results indicate that supplemental MMEY inhibits hyperglycemia, abates oxidative stress, modulates disorders of lipid metabolism, and reduces the impairment of immune function in diabetic mice; especially notable are the protective effects of medium doses of MMEY on the islet cells of diabetic mice. |
| | |
Authors:
|
Jun Liu; Wei Bao; Man Jiang; Yan Zhang; Xiping Zhang; Liegang Liu |
Related Documents
:
|
20185734 - Oral insulin: a comparison with subcutaneous regular human insulin in patients with typ... 833254 - Demonstration of a specific serum carrier protein of nonsuppressible insulin-like activ... 21719174 - Podocytopathy in diabetes: a metabolic and endocrine disorder. 20920444 - Correct use of a new reusable insulin injection pen by patients with diabetes: a design... 19239794 - Acute hypoxic hepatopathy: diabetic ketoacidosis complication in an infant newly diagno... 8603774 - Enhanced expression of platelet-derived growth factor-beta receptor by high glucose. in... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-11-12 |
Journal Detail:
|
Title: Biological trace element research Volume: - ISSN: 1559-0720 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2011-11-14 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7911509 Medline TA: Biol Trace Elem Res Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, 430030, People's Republic of China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Relative Bioavailability of Manganese Proteinate for Broilers Fed a Conventional Corn-Soybean Meal D...
Next Document: Zinc Upregulates the Expression of Osteoprotegerin in Mouse Osteoblasts MC3T3-E1 Through PKC/MAPK Pa...