| Chromium effects on glucose tolerance and insulin sensitivity in persons at risk for diabetes mellitus. | |
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MedLine Citation:
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PMID: 20634174 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate the effects of daily chromium picolinate supplementation on serum measures of glucose tolerance and insulin sensitivity in patients at high risk for type 2 diabetes mellitus. METHODS: We conducted a randomized, double-blind, placebo-controlled, modified cross-over clinical trial with 6-month sequences of intervention and placebo followed by a 6-month postintervention assessment. Adult patients with impaired fasting glucose, impaired glucose tolerance, or metabolic syndrome were enrolled. Participants received 6-month sequences of chromium picolinate or placebo at 1 of 2 dosages (500 or 1000 mcg daily). Primary outcome measures were change in fasting plasma glucose, 2-hour plasma glucose during oral glucose tolerance testing, fasting and 2-hour insulin, and homeostasis model assessment of insulin resistance (HOMA-IR). Secondary outcomes included anthropometric measures, blood pressure, endothelial function, hemoglobin A1c, lipids, and urinary microalbumin. RESULTS: Fifty-nine participants were enrolled. No changes were seen in glucose level, insulin level, or HOMA-IR (all P>.05) after 6 months of chromium at either dosage level (500 mcg or 1000 mcg daily) when compared with placebo. None of the secondary outcomes improved with either chromium dosage compared with placebo (P>.05). CONCLUSIONS: Chromium supplementation does not appear to ameliorate insulin resistance or impaired glucose metabolism in patients at risk for type 2 diabetes and thus is unlikely to attenuate diabetes risk. |
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Authors:
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Ather Ali; Yingying Ma; Jesse Reynolds; John Pierce Wise; Silvio E Inzucchi; David L Katz |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists Volume: 17 ISSN: 1934-2403 ISO Abbreviation: Endocr Pract Publication Date: 2011 Jan-Feb |
Date Detail:
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Created Date: 2011-02-10 Completed Date: 2011-08-01 Revised Date: 2012-02-01 |
Medline Journal Info:
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Nlm Unique ID: 9607439 Medline TA: Endocr Pract Country: United States |
Other Details:
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Languages: eng Pagination: 16-25 Citation Subset: IM |
Affiliation:
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Prevention Research Center, Yale University School of Medicine, Derby, Connecticut 06418, USA. |
| Data Bank Information | |
Bank Name/Acc. No.:
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ClinicalTrials.gov/NCT00067626 |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Blood Glucose / drug effects* Chromium / therapeutic use* Diabetes Mellitus, Type 2 / prevention & control* Double-Blind Method Female Glucose Intolerance / drug therapy* Glucose Tolerance Test Humans Insulin Resistance / physiology* Male Middle Aged |
| Grant Support | |
ID/Acronym/Agency:
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F32 AT002667/AT/NCCAM NIH HHS; F32 AT002667-03/AT/NCCAM NIH HHS; L30 AT004887-02/AT/NCCAM NIH HHS; R01 ES016893-04/ES/NIEHS NIH HHS; R21 AT001332-01A1/AT/NCCAM NIH HHS; R21 AT001332-02/AT/NCCAM NIH HHS; R21 AT001332-02S1/AT/NCCAM NIH HHS; R21 AT1332/AT/NCCAM NIH HHS; U48 DP000053/DP/NCCDPHP CDC HHS; UL1 RR024139/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 7440-47-3/Chromium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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