| Chromatographic resolution and isotherm determination of (R,S)-mandelic acid on Chiralcel-OD column. | |
| | |
MedLine Citation:
|
PMID: 22807393 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Resolution of racemic mandelic acid ((R,S)-MA) and numerical determination of binary competitive isotherm of (R,S)-MA on Chiralcel-OD column have been investigated in this study. The effects of the alcohol modifier and acidic additive in the mobile phase on the retention and enantioseparation of (R,S)-MA were studied at first. The inverse method was then used to determine the competitive isotherm parameters of (R,S)-MA by minimizing the sum of square deviations of the model predictions from the measured elution profiles. The results indicate that the mobile phase with 85% hexane/15% isopropanol/0.3% trifluoroacetic acid mixture gives the best resolution of (R,S)-MA and competitive-modified Langmuir isotherm provides the more accurate sorption mechanism of (R,S)-MA on the cellulose tris(3,5-dimethylphenylcarbamate) chiral stationary phase. |
| | |
Authors:
|
Shimin Mao; Yan Zhang; Sohrab Rohani; Ajay K Ray |
Related Documents
:
|
22799633 - Fatty acid composition of muscle tissue measured in amphibians living in radiologically... 575503 - Purification of a basic somatomedin, from human plasma cohn fraction iv-1, with physico... 21865563 - Low maternal vitamin b-12 status is associated with offspring insulin resistance regard... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-7-17 |
Journal Detail:
|
Title: Journal of separation science Volume: - ISSN: 1615-9314 ISO Abbreviation: - Publication Date: 2012 Jul |
Date Detail:
|
Created Date: 2012-7-18 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101088554 Medline TA: J Sep Sci Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Affiliation:
|
Department of Chemical and Biochemical Engineering, The University of Western Ontario, London, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Photophysical and Electrochemical Properties, and Molecular Structures of Organic Dyes for Dye-Sensi...
Next Document: Molecular alterations in endometrial archived liquid-based cytology.