Document Detail

Chromatographic and mass spectrometric fingerprinting analyses of Angelica sinensis (Oliv.) Diels-derived dietary supplements.
MedLine Citation:
PMID:  23314619     Owner:  NLM     Status:  MEDLINE    
Angelica sinensis (Oliv.) Diels ("Danggui" in Chinese) is one of the most commonly used traditional Chinese medicines. It has been used to invigorate blood circulation for the treatment of anemia, hypertension, chronic bronchitis, asthma, rheumatism, and cardiovascular diseases. There are a number of A. sinensis-derived dietary supplements in the US markets. However, no study have been conducted to investigate the quality of these dietary supplements. In this paper, high-performance liquid chromatographic and flow-injection mass spectrometric fingerprints were both evaluated to assess the consistency of A. sinensis-derived dietary supplements. Similarity analysis was carried out on the high-performance liquid chromatographic (HPLC) fingerprints. Meanwhile, principal component analysis (PCA) was performed on the data obtained from flow-injection mass spectrometric (FIMS) fingerprints, which can analyze each sample in 2 min, compared with 30 min required for the chromatographic fingerprint. Both methods show significant chemical differences between samples that may be due to differences in growing locations, growing conditions, harvesting times, and/or botanical processing. The loading plots obtained from PCA singled out the discriminatory ions that were responsible for chemical differences of A. sinensis-derived dietary supplements.
Yang Zhao; Jianghao Sun; Liangli Lucy Yu; Pei Chen
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2013-01-15
Journal Detail:
Title:  Analytical and bioanalytical chemistry     Volume:  405     ISSN:  1618-2650     ISO Abbreviation:  Anal Bioanal Chem     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-22     Completed Date:  2013-10-21     Revised Date:  2014-05-07    
Medline Journal Info:
Nlm Unique ID:  101134327     Medline TA:  Anal Bioanal Chem     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  4477-85     Citation Subset:  IM    
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MeSH Terms
Angelica sinensis / chemistry*
Chromatography, High Pressure Liquid / methods
Dietary Supplements / analysis*
Drugs, Chinese Herbal / analysis*,  chemistry
Flow Injection Analysis / methods,  statistics & numerical data*
Mass Spectrometry / methods
Principal Component Analysis
Grant Support
Y01 OD001298-01/OD/NIH HHS
Reg. No./Substance:
0/Drugs, Chinese Herbal

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