| Chromatographic fingerprinting and metabolomics for quality control of TCM. | |
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MedLine Citation:
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PMID: 20883190 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Chromatographic fingerprinting technique of traditional Chinese medicine (TCM) has proved to be a comprehensive strategy for assessing the intact quality of herbal medicine. In general, one could use the chromatographic techniques to obtain a relatively complete picture of herbal medicines, which are in common called chromatographic fingerprints of herbal medicines to represent the so-called phytoequivalence. Based on this, the features of chromatographic fingerprints of herbal medicines have been discussed in some detail. The technique based on chromatographic fingerprinting is essentially a kind of high-throughput and integral tools to explore the complexity of herbal medicines. In order to further control the comprehensive quality of TCMs, some new strategies are proposed to trace the chemical changes of chromatographic fingerprints both in product processing and/or after their administration by modern chromatographic techniques and chemometrics. Combined with metabolomics, it seems possible for one to reveal the working mechanism of TCMs and to further control their intrinsic quality. Finally, the intensive study of chromatographic fingerprinting coupled with multivariate analysis tools developed in bioinformatics and chemometrics are emphasized in order to achieve the aim to reveal the working mechanisms of TCMs and to further control and strengthen TCMs' intrinsic quality in a comprehensive manner. |
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Authors:
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Yi-Zeng Liang; Pei-Shan Xie; Kelvin Chan |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Combinatorial chemistry & high throughput screening Volume: 13 ISSN: 1875-5402 ISO Abbreviation: Comb. Chem. High Throughput Screen. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9810948 Medline TA: Comb Chem High Throughput Screen Country: Netherlands |
Other Details:
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Languages: eng Pagination: 943-53 Citation Subset: IM |
Affiliation:
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Research Center of Modernization of Chinese Medicines, Central South University, Changsha 410083, China. yizeng_liang@263.net |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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