Document Detail

Chromatin organization of gammaherpesvirus latent genomes.
MedLine Citation:
PMID:  19853673     Owner:  NLM     Status:  MEDLINE    
The gammaherpesviruses are a subclass of the herpesvirus family that establish stable latent infections in proliferating lymphoid and epithelial cells. The latent genomes are maintained as multicopy chromatinized episomes that replicate in synchrony with the cellular genome. Importantly, most of the episomes do not integrate into the host chromosome. Therefore, it is essential that the viral "minichromosome" establish a chromatin structure that is suitable for gene expression, DNA replication, and chromosome segregation. Evidence suggests that chromatin organization is important for each of these functions and plays a regulatory role in the establishment and maintenance of latent infection. Here, we review recent studies on the chromatin organization of the human gammaherpesviruses, Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV). We discuss the potential role of viral origins of DNA replication and viral encoded origin-binding proteins like EBNA1 and LANA in establishment of viral chromosome organization during latent infection. We also discuss the roles of host cell factors, like CTCF and cohesins, that contribute to higher-order chromosome structures that may be important for stable gene expression programs during latent infection in proliferating cells.
Italo Tempera; Paul M Lieberman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2009-10-22
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1799     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:    2010 Mar-Apr
Date Detail:
Created Date:  2010-03-15     Completed Date:  2010-05-11     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  236-45     Citation Subset:  IM    
Copyright Information:
2009 Elsevier B.V. All rights reserved.
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MeSH Terms
Chromatin / physiology*
DNA, Viral / genetics
Gammaherpesvirinae / genetics*
Genome, Viral*
Virus Latency / genetics*
Virus Replication
Grant Support
CA093606/CA/NCI NIH HHS; CA117830/CA/NCI NIH HHS; DE017336/DE/NIDCR NIH HHS; R01 CA093606/CA/NCI NIH HHS; R01 CA093606-06A2/CA/NCI NIH HHS; R01 CA093606-07/CA/NCI NIH HHS; R01 CA117830/CA/NCI NIH HHS; R01 CA117830-03/CA/NCI NIH HHS; R01 CA117830-04/CA/NCI NIH HHS; R01 DE017336/DE/NIDCR NIH HHS; R01 DE017336-02/DE/NIDCR NIH HHS; R01 DE017336-03/DE/NIDCR NIH HHS
Reg. No./Substance:
0/Chromatin; 0/DNA, Viral

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