Document Detail


Chromatin organization and cell fate switch respond to positional information in Arabidopsis.
MedLine Citation:
PMID:  16362059     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Many types of plant cell retain their developmental plasticity and have the capacity to switch fate when exposed to a new source of positional information. In the root epidermis of Arabidopsis, cells differentiate in alternating files of hair cells and non-hair cells, in response to positional information and the activity of the homoeodomain transcription factor GLABRA2 (GL2) in future non-hair cells. Here we show by three-dimensional fluorescence in situ hybridization on intact root epidermal tissue that alternative states of chromatin organization around the GL2 locus are required to control position-dependent cell-type specification. When, as a result of an atypical cell division, a cell is displaced from a hair file into a non-hair file, it switches fate. We show that during this event the chromatin state around the GL2 locus is not inherited, but is reorganized in the G1 phase of the cell cycle in response to local positional information. This ability to remodel chromatin organization may provide the basis for the plasticity in plant cell fate changes.
Authors:
Silvia Costa; Peter Shaw
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-12-18
Journal Detail:
Title:  Nature     Volume:  439     ISSN:  1476-4687     ISO Abbreviation:  Nature     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2006-01-26     Completed Date:  2006-02-13     Revised Date:  2006-11-20    
Medline Journal Info:
Nlm Unique ID:  0410462     Medline TA:  Nature     Country:  England    
Other Details:
Languages:  eng     Pagination:  493-6     Citation Subset:  IM    
Affiliation:
Department of Cell and Developmental Biology, John Innes Centre, Norwich NR4 7UH, UK.
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MeSH Terms
Descriptor/Qualifier:
Arabidopsis / anatomy & histology*,  cytology*,  genetics,  metabolism
Arabidopsis Proteins / genetics,  metabolism
Cell Differentiation*
Cell Division
Cell Lineage*
Chromatin / genetics*,  metabolism*
Chromatin Assembly and Disassembly*
DNA-Binding Proteins / genetics
G1 Phase
Gene Expression Regulation, Plant
Homeodomain Proteins / genetics,  metabolism
In Situ Hybridization, Fluorescence
Meristem / cytology,  metabolism
Organ Specificity
Plant Epidermis / cytology,  metabolism
Plant Proteins / genetics
Plant Roots / cytology
Proto-Oncogene Proteins c-myb / genetics
Chemical
Reg. No./Substance:
0/ATR1 protein, Arabidopsis; 0/Arabidopsis Proteins; 0/CPC protein, Arabidopsis; 0/Chromatin; 0/DNA-Binding Proteins; 0/FAS protein, Arabidopsis; 0/GL2 protein, Arabidopsis; 0/Homeodomain Proteins; 0/Plant Proteins; 0/Proto-Oncogene Proteins c-myb; 0/WER protein, Arabidopsis

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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